Immunoaffinity, Capillary Electrophoresis, and Statistics for Studying Intact Alpha 1-Acid Glycoprotein Isoforms as an Atherothrombosis Biomarker
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Last Update: 2020-12-08
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Source: Internet
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Author: User
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Variations in the amino acid sequence, glycosylation, and/or other posttranslational modifications in glycoproteins give riseto different molecules of the glycoprotein called forms. Qualitative and/or quantitative alterations in these forms are relatedto pathophysiological situations in the individuals. In this study, a methodology to analyze these differences in forms ofthe alpha 1-acid glycoprotein (AGP) between healthy individuals and patients with two different vascular diseases is detailed. The whole methodology includes a sample preparation method based on immunochromatography, a capillary electrophoresis methodfor separation of AGP peaks (isoforms), and statistical methods (Linear Discriminant Analysis) for sample classification. As a result, it is shown that the methodology proposed allows studying the role of AGP isoforms as potential vascular diseasebiomarkers.
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