Impaired white matter integrity in patients with Alzheimer's disease gene mutations

People with autosomal dominant Alzheimer's disease (ADAD) mutations have a higher risk of Alzheimer's disease

"It is thought that amyloid deposits in gray matter may disrupt its function, so white matter will not work properly and may even shrink," said lead author of the study, Dr.

An early study by Dr.

Jeffrey R.

In this new study, Dr.

The study participants included 30 mutation carriers with an average age of 34 years and 38 non-carriers with an average age of 37 years

Analysis shows that the frontal-parietal lobe control network structure of mutation carriers is less connected.

"This shows that DTI's measurement of network integrity can be used as a substitute for the brain's ability to recover from pathological attacks," said Dr.

"We use a network measurement method called global efficiency, in which the reduction in efficiency can be seen as a breakdown of the network organization," Dr.

The results of the study support a potential role in identifying changes in the brain structure of people who are genetically at risk of early-onset Alzheimer's disease based on imaging technology to understand how genes affect the disease process that leads to dementia

Dr.

This finding also points to the role of imaging technology in the research of drugs for the treatment of Alzheimer's disease

Dr.

Researchers hope to use advanced imaging technology and updated data from the DIAN network for follow-up studies to evaluate the progress of research participants in Alzheimer's disease

Jeffrey W.