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Researchers report that sequencing of RNA blood samples found that the down-regulation of specific immune system-fighting cells is related to MIS-C, which is a continuous inflammatory response
MIS-C is characterized by fever, pain, and inflammation of multiple organs, including the heart, lungs, kidneys, skin, eyes, or gastrointestinal tract
One of the more important gene networks involves the suppression of two types of immune cells: natural killer (NK) cells and CD8+ T cells
"Our study shows that T cell failure in misc patients is one of the potential drivers of this disease, indicating that the increase in NK cells and circulatory failure CD8+ T cells may improve the symptoms of inflammatory diseases," Noam Beckmann, the main co-author of the study The doctor said that he is an assistant professor of genetics and genomic sciences
Dr.
Mount Sinai Hospital’s work on MIS-C is the first gene expression study of the hospital’s COVID-19 biobank
Journal Reference :
Beckmann, ND, Comella, PH, Cheng, E.