Important progress has been made in the research on the mechanism of the activation of novel small molecules by the communication between the fungi where microorganisms are located

The living environment of fungi is very complex.

5pt;line-height:180%;font-family:"",sans-serif; mso-bidi-font-family:Helvetica'>Yin Wenbing's research group at the Institute of Microbiology, Chinese Academy of Sciences has been working on the gene regulation mechanism and function of fungal secondary metabolites

5pt;line-height:180%;font-family:"",sans-serif; mso-bidi-font-family:Helvetica'>However, how is this response achieved? Taking the co-culture system of Aspergillus nidulans and Dendrobium as a model, Yin Wenbing's research group analyzed the mechanism of its response from the aspects of biology, chemistry and genetics

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5pt;font-family:"",sans-serif; mso-bidi-font-family:Helvetica;color:#444444'>Figure 1.

5pt;line-height:180%;font-family:"",sans-serif; mso-bidi-font-family:Helvetica'>This study is the first to propose the metabolic regulation function of the partially functionally deficient VeA1 protein, revealing that the co-culture between fungi is mediated by VeA1 , through the LaeA-VeA1-VelB complex, and then through the complex response regulatory network of the downstream transcription factor SclB (Fig.

5pt; line-height:180%;font-family:"",sans-serif;mso-bidi-font-family:Helvetica; color:#444444'>Figure 2Schematic diagram of the regulatory mechanism of global changes in secondary metabolites under fungal - fungus co-culture conditions

5pt;line-height:180%; font-family:"",sans-serif;mso-bidi-font-family:Helvetica'>The above research results were quickly published in the international journal Science Advances ( https:// ) in the form of a research article , entitled " Fungal-fungal cocultivation leads to widespread secondary metabolite " alteration requiring the partial loss-of-function VeA1 protein ” .