Important progress in research and development of antifungal agents in China

In recent years, due to the wide application of new treatment technologies such as anti rejection after organ transplantation and tumor intensive chemotherapy, the number of people with low immune function has increased year by year, making the incidence of invasive fungal infection significantly increased Recently, great progress has been made in the research of anti fungal infection monoclonal antibody drugs with independent intellectual property rights, which is expected to realize industrialization (on July 11, Tongji University and Maiwei (Shanghai) Biotechnology Co., Ltd signed a technology transfer agreement of 30 million yuan Xu Jing) great progress has been made in the research and development of a new generation of monoclonal antibody against fungal infection in China On July 11, Tongji University and Maiwei (Shanghai) Biotechnology Co., Ltd signed a technology transfer agreement of 30 million yuan to jointly develop anti fungal monoclonal antibody drugs with independent intellectual property rights on the basis of research and development achievements of Medical College of Tongji University After the industrialization of this achievement, it will become a more effective drug for the prevention and treatment of invasive fungal infection, and fill the blank of antibody drugs in this field in China The scientific research achievements of this transfer come from Jiang Yuanying / an Maomao research team of Medical College of Tongji University, led by Professor Jiang Yuanying, a scientist of "973 Plan", an Maomao is in charge of specific research and development management, has been engaged in the research on the mechanism of fungal resistance and the development of antifungal drugs for a long time, and has successfully established the technology of drug-forming research and preclinical pharmacodynamic evaluation of antifungal drugs Platform, in the field of antifungal drug research in China After five years of research and development, the research team obtained monoclonal antibody molecules against highly conserved proteins on fungal cell walls The antibody molecule showed strong antifungal activity in various kinds of animal infection models It can effectively reduce the bacteria load and pathological damage of infected organs, significantly prolong the survival period of experimental animals, and has good pharmacokinetic characteristics, and has the feasibility of cooperation into preclinical research In recent years, due to the wide application of new treatment technologies such as anti rejection after organ transplantation and tumor intensive chemotherapy, the number of people with low immune function has increased year by year, making the incidence of invasive fungal infection significantly increased Invasive fungal infection has a high mortality, the root of which lies in the slow progress of research and development of antifungal drugs, the lack of clinically applicable varieties and easy to produce drug resistance Therefore, new targets, new mechanisms and a wider range of innovative drugs are urgently needed to meet the clinical needs Antibody drugs, as a new type of drugs, have been developing rapidly in recent 20 years Their R & D in the field of anti infection has been favored by large pharmaceutical companies such as GlaxoSmithKline and mosadon and many small innovative biotechnology companies, and they have been actively distributed among them Maiwei (Shanghai) Biotechnology Co., Ltd is registered in China (Shanghai) pilot free trade zone It is mainly engaged in the research and development and industrialization of macromolecular drugs It has good foundation and rich experience in the research and development and industrialization of monoclonal antibody drugs Liu Datao, President of the company, said that the company has taken the research and development and industrialization of anti infective antibody drugs as an important direction of the company's development, and will cooperate with Tongji University to give full play to the research and development advantages of Jiang Yuanying / an Maomao research team in the field of anti infective drugs, realize strong cooperation, and jointly promote the cooperative varieties to the stage of industrialization; At the same time, on the basis of this cooperative research, the company will further sign a strategic cooperation framework agreement with Tongji University, and conduct long-term and in-depth cooperation in the field of anti infective innovative drug research The reporter learned that Tongji University will, according to the relevant policies on the transformation of scientific and technological achievements of Tongji University, use the proceeds obtained to motivate team researchers, strengthen personnel training, purchase large-scale instruments and equipment, further improve the team's scientific research ability, and form a batch of scientific research achievements with higher level and more quantity In recent years, Tongji University has made great efforts to improve the overall scientific research strength of the University, at the same time, it has actively innovated the system and mechanism of transformation of scientific and technological achievements, opened up the "paper" into the "money" one kilometer later, in order to play the great benefits of scientific and technological achievements The University actively promotes the cooperation between various disciplines and enterprises in production, learning and research, and promotes the landing of more scientific and technological achievements; In terms of scientific research management, scientific research achievements transfer process service, income distribution and management, as well as incentives for scientific researchers, we have innovated the mechanism and system, and introduced relevant policies, including transforming the traditional "scientific and Technological Research Institute" into "one department and three institutes", namely "scientific research management department, scientific and Technological Research Institute, engineering and Industrial Research Institute, advanced technology research institute", and introducing the first three institutes In order to improve the ability of Tongji University to serve the society in an all-round way, we should include teachers' performance in serving the society into Teachers' performance assessment, and add "social service" into Teachers' professional title evaluation.