In-body production of red blood cells helps solve the world's problems of blood shortage

At present, red blood cells and other blood products are mainly derived from volunteer exo-weekly blood donation, insufficient donors, infection risk, rare blood type deficiency, etc. are still the world's blood transfusion problems.
in-body induced erythrogenic stem cells targeted differentiation into red blood cells is another important way to solve the above problems, but the erythrial ancestral cell dekerneling efficiency of erythrogen stem cell differentiation source is very low, it is difficult to produce enough mature red blood cells.
to obtain large numbers of functional red blood cells through in-body culture is an important challenge in this field.
through a detailed analysis of cd235a plus red line ancestral cells of a single nuclear cell of healthy exoded blood, the researchers found that red line ancestral cells could not maintain a state of self-renewal for a long time, and rapidly differentiated and then apoptosis.
high-volume sequencing results show that with the differentiation of introphy culture of red line progenitor cells mature, BMI1 gene expression is rapidly reduced, exogenetic over-expression of BMI1 can enable red line progenitor cells to maintain the ability to self-renewal, in the culture system constantly expanded, 2 months can be expanded up to 10 trillion times.
, the study also found that BMI1 had the same effect on red line ancestral cells from patients with sickle anemia.
will induce mature red blood cells after denuclearization to enter the blood transfusion model mice through tail intravenous injection, and found that the cultured source of human red blood cells have the same in vivo circulation function as normal weekly blood source red blood cells.
, the team also confirmed that in-body amplified red line ancestral cells can be further genetically engineered to meet a wider range of precision medicine.
(Reporter Wu Changfeng)