Indian scientists have found that certain areas of DNA are protected from radiation
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Last Update: 2021-03-02
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Source: Internet
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Author: User
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, Nov. 25 (Xinhua) -- A recent Indian study found that certain areas of human DNA are protected from radiation, a finding that is critical to maintaining the stability of the human genome. The findings were published online online in the journal iScience, part of the American Cell Press.
human genome is constantly challenged by endogeneic and exogenetative damage, and maintaining genomic stability is critical to the survival of any organism. Among the exodisective factors, ionizing radiation is the most important factor causing DNA damage, which can lead to the fracture of single and double strands. It is generally believed that ionizing radiation induces DNA strand breakage in a random manner.
to study the relationship between DNA structure types and radiation resistance, researchers at the Indian Institute of Science first began testing with single-stranded DNA. When a DNA strand consisting entirely of one of the four nucleotides (adenine, cytosine, ostrich, or thymus) is exposed to gamma rays, all DNA strands are sensitive to radiation except ostrich. When half of a DNA strand contains thymus and the other half contains ostrich, only half of the ostrich exhibits better radiation resistance.
the researchers then tested the resistance to radiation in a related structure consisting of ostrich, and found that G-four-stranded DNA, which is rich in series repeat ostrich (G), was the most resistant to radiation.
researchers say the results show that the G-four-strand structure avoids radiation-induced DNA fractures and is more resistant to radiation, and that G-four-stranded DNA is an important factor in the differences in radiation sensitivity in the human genome.
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