Individual differences in patients with the new coronavirus? Does this have to do with human genes?

Beijing time, May 6, according to foreign media reports, genetic components of individual differences may explain the human susceptibility to the new coronavirus, as well as the severity of the disease.
Since the outbreak of the new crown outbreak a few months ago, scientists have been trying to explore ways to analyze the virus's different manifestations, ranging from totally non-symptomatic cases to severe cases involving acute respiratory distress syndrome, which can lead to the death of patients, and what contributes to individual differences in patients with the new coronavirus? Does this have to do with human genes? Researchers are once again interested in TLRs receptors for the new coronavirus currently ravaging the world, which may help explain the high number of men who are severely infected.
figure, researchers are testing blood types.
scientists have been questioning the coronavirus for more than a decade, as early as the 2003 global outbreak of sars virus, ralph Baric of the University of North Carolina at Chapel Hill and colleagues in the United States found a gene that, once mutated and suppressed, made the test mice susceptible to SARS virus infection.
gene, called TICAM2, it encodes proteins to activate a series of receptors called bell receptors (TLRs), which are associated with the innate immune system and are the first line of defense against pathogens.
researchers are once again interested in TLRs receptors for the new coronavirus currently ravaging the world, which may help explain the high number of men who are severely infected.
April 23, a French survey showed that male patients with the new coronavirus accounted for 73% of the total number of patients in the intensive care unit of French hospitals, and that their behavioral characteristics and hormonal differences may be related, but genes may be one of the factors in the mix, unlike men, women have two X chromosomes and therefore carry twice the TLRs gene, an important test of viral activity that helps boost immunity.
blood type genetics can identify whether people are susceptible to infection with the virus, the researchers found that the A blood type appears to be associated with a higher risk of infection with the virus, and the O blood type is the most protective effect, the specific reason is not clear.
the SARS virus that broke out in 2003 provides some lessons for the presence of two different sugar molecules on the surface of red blood cells, each of which is produced by an enzyme that has two genes: Type A and B.
a third gene variant encodes an inactive enzyme, type O, and the person with the variants A and B enzymes is the AB blood type.
each sugar molecule (type A or B) can be used as an antigen, which can trigger the production of antibodies against the antigen it lacks, which is why people must be very careful when giving blood transfusions.
in the ABO blood type system, O blood type people body antibodies are the most abundant, it has both A and B antibodies, while AB blood type people do not have these two antibodies.
2008, Jacques Le Pendu, a researcher at the University of Nantes in France, and colleagues studied in vitro model samples of the SARS virus, and the results showed that the binding of viral protein S with cell ACE2 (type 2 vascular tension peptide conversion enzyme) receptors is a necessary process of viral infection, which is inhibited by type A antibodies, but their research data on type B antibodies is still very scarce.
in the process of blood pressure control, a close relative of ACE2 is "type 1 vascular tension peptide conversion enzyme (ACE1)," the ACE1D gene is one of several gene mutations of the conversion enzyme, and the final cell allows the infection of SARS virus receptors significantly reduced.
the emergence of the ACE1D gene is related to the countries and regions in which people live, especially in Europe, scientists believe that the geographical distribution of the mutated gene population is related to the spread of the new coronavirus, does this index reflect the global spread of the new coronavirus? 'It's true,' said Marc DeBuyzere, a researcher at the University of Ghent in Belgium, and my colleagues believe that the ACE1D gene is closely related to the susceptibility of the new coronavirus.
based on research data from 25 countries, including Portugal, Estonia, Turkey, Finland, etc., the researchers found that 38 per cent of changes in the prevalence of the new coronavirus can be explained by the frequency of ACE1D genes, and a similar correlation was shown in mortality statistics.
they say the ACE1 gene is less frequent in Asian countries with severe infections with the new coronavirus.
more genetic components of the susceptibility of the new coronavirus may be related to the genetic coding of human leukocyte antigens (HLAs), a group of proteins that prevent the body's immune system from viruses, forming a "major tissue compatibility complex ( MHC) that marks "self-composition" and distinguishes it from "non-self-components."
now, Reid Thompson, a researcher at Oregon Health Sciences University in the United States, and colleagues have found a close relationship between specific HLA genes and the level of new coronavirus infection.
Thompson says a mutant gene called "HLA-B"46:01 is more susceptible to SARS, as has been demonstrated as a new coronavirus susceptibility, compared with the HLA-B-15:03 gene that may provide some protection.
by identifying someone's HLA genetic characteristics, you can quickly and cheaply complete tests that may help better predict the extent of infection and even help determine who will be better vaccinated.
(Ye-ChengCheng) Source: Sina Technology.