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Original title: Intestinal Microbial Deficiency Infants Are Allergic to Food
A mouse study published in Scientific Progress found that young
immune
systems are sensitive to food
orients
if they do not have the correct gut
bugs
.
Sung-Wook Hong of the Korea Institute of Basic Sciences and colleagues have been studying the effects of micro
life
on allergies and the immune system. They wanted to know why mice that grew up in sterile environments without gut microbes suddenly produced high levels of antibodies when they ate solid food after weaning.
these immunoglobulin E (IgE) antibodies form the immune system "arm" that mediats allergic reactions to specific chemicals. When IgE antibodies detect allergens, they trigger the release of inflammatory chemicals that cause allergy symptoms.
To understand why IgE proliferated in mice that did not have microbes during weaning, the researchers fed the mice normal food, or only foods containing essential amino acids, vitamins and glucose , which had nothing to stimulate the immune system. They found that mice on a normal diet spontaneously developed an immune response, while mice without an antigen diet did not.
suggests a link between a lack of a healthy gut microbiome and a food-induced immune response in mice, according to Hong.
, however, when the team delayed the introduction of normal solid foods until microbial-free mice in the body reached adults, they found that the mice produced fewer IgE antibodies.
study found that a special type of immune cell called T-filter-assisted cells was involved in the IgE response in mice. This T-cell is produced mainly in the early stages of life.
the findings could help explain why children are more susceptible to allergies than adults, said Hong.
when the researchers mixed microbial-free mice with normal mice, they found that they stopped producing the same number of T-filter-assisted cells and that IgE antibody levels dropped.
of this study is that when you eat food antigens, it's important to see what happens to the microbiome in your body," he said. Emma Hamilton-Williams, of the University of Queensland in Australia, says the gut microbiome is really growing and changing in the first year of life, so it's definitely linked.
, good gut bacteria can be killed by antibiotics, disease or radiation. Elissa Deenick, of the University of New South Wales, said the latest findings raise the question of how long certain foods should be given to young children after antibiotics are used.
relevant paper information: DOI:10.1126/sciadv.aaw1507.