Approximately 10 million people were infected with tuberculosis (TB) in 2018.
At present, tuberculosis management is paying more and more attention to the extrapulmonary manifestations of the disease, as the proportion of extrapulmonary tuberculosis (EPTB) has increased by 50% in some areas
.
Nevertheless, compared with tuberculosis (PTB), EPTB is still largely ignored by public health and clinicians
.
In PTB, the best research biomarker for successful treatment is conversion to negative sputum culture, but this is not suitable for most patients with EPTB who require repeated invasive tissue sampling
.
Therefore, there is an urgent need to validate alternative biomarkers of treatment response in EPTB in order to shorten the duration of treatment
.
Interferon (IFN)-γ-inducible protein 10 (IP-10), a pro-inflammatory chemokine secreted by a variety of immune cells, has been proposed as a substitute for PTB treatment response.
Therefore, this study aims to Assess the level of IP-10 in the treatment of EPTB patients, and prospectively analyze the clinical characteristics of EPTB patients
.
At present, tuberculosis management is paying more and more attention to the extrapulmonary manifestations of the disease, as the proportion of extrapulmonary tuberculosis (EPTB) has increased by 50% in some areas.
Infection management immunity
This study was conducted at the Cologne University Hospital, and 20 EPTB patients were included in this study
.
During the 12-month treatment, the researchers analyzed the plasma interferon-γ-inducible protein 10 (IP-10) level in the patient's plasma by ELISA
.
In addition, the QuantiFERON ® -TB Gold Plus (QFT ® Plus) test was carried out during the treatment process to test positive for tuberculosis bacteria
.
The results of the study found that compared with healthy controls, patients with tuberculosis external pulmonary phenotypic disease had significantly increased plasma IP-10 levels (p <0.
001)
.
In patients with clinically proven tuberculosis, the level of IP-10 further increases
.
During the treatment, the IFN-γ level measured by the QFT ® Plus test did not decrease significantly
.
It is worth noting that in four EPTB patients (20%) without lung involvement in imaging studies, sputum cultures were positive for Mycobacterium tuberculosis
.
Therefore, sputum culture is still the gold standard for detection of EPTB patients
.
.
Figure: The relationship between the severity of extrapulmonary tuberculosis and IP-10
This study confirmed that IP-10 may be the most valuable biomarker for assessing the severity of EPTB disease
.
The QFT ® Plus test does not seem to be a good diagnosis for pulmonary tuberculosis patients , so the sputum of EPTB patients should be checked even if the chest diagnostic imaging is normal
.
.
The QFT ® Plus test does not seem to be a good diagnosis for pulmonary tuberculosis patients , so the sputum of EPTB patients should be checked even if the chest diagnostic imaging is normal
.
diagnosis
Original source:
Isabelle Suárez.
Et al.
Plasma interferon-γ-inducible protein 10 (IP-10) levels correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis.
Infection.
2021 .
Leave a message here
