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A Phase II clinical trial showed that icodec insulin is used in adult type 2 diabetics in blood sugar control and safety characteristics similar to the daily injection of insulin glycerion U100.
The 26-week study included 247 adult type 2 diabetics who had not previously used insulin, who had not previously used metformin, who had not used metformin or who did not use DEP-4i, and were designed to compare the efficacy and safety differences between icodec insulin injected once a week and insulin glyceride U100 injected daily.
end point is the HbA1c change from baseline to 26 weeks.
end points include changes in peri-abdominal blood sugar from baseline to 26 weeks and the number of hypoglycemia events.
results showed that participants who received weekly injections of icodec insulin from baseline to 26 weeks had similar changes in blood sugar control (HbA1c) to participants who received daily insulin insulin glycemic U100 treatment (-1.33% vs-1.15%, p-0.08, respectively) to reach the primary endpoint.
secondary endpoints included changes in peri-abdominal blood sugar from baseline to 26 weeks, similar changes in the icodec insulin group and insulin glycemic U100 (-58mg/dL and -54mg/dL, respectively); p - 0.01).
safety, the rates of hypoglycemia were similar in the two treatment groups, and no new safety issues associated with icodec insulin were found.
icodec insulin is a long-acting underlying insulin similar in study with a half-life of 196 hours.
icodec insulin binds tightly but reversiblely to albumin when injected into the body.
results can reduce blood sugar continuously, slowly and steadily over a period of one week.
based on its concentrated formula, the amount of icodec insulin injected once a week is comparable to the amount of insulin Glycelin U100 injected daily.
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