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    Home > Food News > Nutrition News > Injectable microtissue protects muscle function in sciaticotomized rats

    Injectable microtissue protects muscle function in sciaticotomized rats

    • Last Update: 2022-05-28
    • Source: Internet
    • Author: User
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    The researchers severed the sciatic nerves of rats and injected them with TE-NMI or microscopic tissue without any neurons
    .
    In the group that received the TE-NMI, the researchers were able to electrically stimulate the nerve stump "guarded" by the TE-NMI and record the muscle response five months after the tissue was implanted

    .
    No muscle response was detected in the control group

    .

    "Thousands of patients undergo nerve damage repair surgery every year, and even if the surgeon does a perfect operation, they can't get the axon to regenerate faster than about an inch a month
    .
    For nerve injuries in the upper arm or extremity, regeneration may It takes years; however, the pathways connecting the muscles and the muscles themselves will irreversibly degenerate after 6 to 12 months, leading to permanent loss of motor and sensory function," said senior author D.
    Kacy Cullen, Ph.
    Associate Professor of Surgery

    .
    "By increasing the time window during which a patient's axon reconnects to the muscle, this study has the potential to improve patient recovery without causing further damage

    .
    "

    For example, a patient who suffers a brachial plexus injury (a nerve root tear where the nerve is pulled away from the spinal cord) may regain elbow function but may never regain hand function
    .
    In these cases, neurosurgeons typically cut open a healthy nerve near the hand and then redirect it, stimulating the hand muscles to restore some function while the nerve regrows

    .
    The researchers say te-NMI may be done more thoroughly without having to damage a patient's healthy nerves

    .

    "Working closely with clinicians at Penn Neurosurgery, we identified a potential surgical model that would be most helpful to them and their patients," said first author Justin Burrell, PhD, neurosurgery and translational medicine Postdoctoral fellow at the Institute for Therapeutics
    .
    "More importantly, as we continue to test and reiterate our findings, we will continue to work with the Neurocenter to ensure our research provides them with the technology they need to provide the best possible care for their patients

    .
    "

    This research was primarily supported by the U.
    S.
    Department of Defense (W81XWH-16-1-0796, W81XWH-19-1-0867), the National Institutes of Health (R44-NS108869, TL1-TR001880), and the Department of Veterans Affairs (I01-BX003748)

    .

    Journal Reference :

    1. Justin C.
      Burrell, Suradip Das, Franco A.
      Laimo, Kritika S.
      Katiyar, Kevin D.
      Browne, Robert B.
      Shultz, Vishal J.
      Tien, Phuong T.
      Vu, Dmitriy Petrov, Zarina S.
      Ali, Joseph M.
      Rosen , D.
      Kacy Cullen.
      Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats .
      Bioactive Materials , 2022; 18: 339 DOI: 10.
      1016/j.
      bioactmat.
      2022.
      03.
      018


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