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    Home > Biochemistry News > Biotechnology News > Innovative combination of RNA activation therapy for first-line treatment of advanced liver cancer enters the clinic

    Innovative combination of RNA activation therapy for first-line treatment of advanced liver cancer enters the clinic

    • Last Update: 2022-01-12
    • Source: Internet
    • Author: User
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    On December 1, 2021, the Cancer Institute of the National University of Singapore (NCIS) and MiNA Therapeutics jointly announced that MiNA's small-activated RNA therapy MTL-CEBPA, combined with standard treatments atezolizumab and bevacizumab (bevacizumab), is the first-line treatment for advanced liver The phase 1 clinical trial for patients with cell carcinoma (HCC) has completed the first patient's administration
    .
    Atezolizumab is a PD-L1 inhibitor.
    The combination of treatment with anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is the first first-line immunotherapy for liver cancer approved by the FDA

    .

    Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide
    .
    According to statistics, more than 750,000 people worldwide suffer from hepatocellular carcinoma each year, most of which occur in Asia, and almost half of the cases are in China

    .
    The main causes of HCC are chronic hepatitis caused by hepatitis B or C virus infection, and liver cirrhosis caused by drinking or non-alcoholic steatohepatitis

    .

    The phenomenon that can specifically up-regulate targeted genes is called RNA activation (RNAa), and those small double-stranded RNAs with RNAa function are called small activating RNA (saRNA)
    .
    The chemical structure of saRNA is similar to siRNA, it recruits the endogenous transcription complex to the target gene, resulting in increased mRNA expression and up-regulation of target protein expression

    .

    The press release pointed out that MTL-CEBPA is the first therapy to specifically upregulate CCAAT/enhancer binding protein alpha (C/EBP-α).
    CCAAT/enhancer binding protein alpha is a transcription factor that determines the lineage of myeloid cells.
    The main regulator of differentiation

    .
    Disorders of myeloid cells are related to many diseases

    .
    MTL-CEBPA aims to restore the C/EBP-α protein to normal levels through the RNA activation mechanism and reduce the immunosuppressive effect of myeloid cells

    .
    It is composed of double-stranded RNA encapsulated by liposomal nanoparticles

    .
    In preclinical studies, it has been proven that MTL-CEBPA can improve the anti-tumor activity of cancer treatment by targeting dysregulated myeloid cells and reducing their inhibitory effect in the tumor microenvironment

    .

    The open-label Phase 1 trial will enroll approximately 30 patients with unresectable or advanced HCC who have not received systemic therapy in the past
    .
    The main purpose of the dose escalation phase is to determine dose-limiting toxicity, and the primary end point of the dose extension phase is the patient’s objective response rate (ORR)

    .
    The trial is expected to obtain data in 2023

    .

    Reference materials:

    [1] National University Cancer Institute, Singapore and MiNA Therapeutics Announce Initiation of a Phase 1 Clinical Study of MTL-CEBPA in Combination With First-line Standard of Care in Advanced Liver Cancer.
    Retrieved December 1, 2021, from https://www .
    businesswire.
    com/news/home/20211130005712/en

    (The original text has been deleted)

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