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I forgot where I was and what I wanted to do, lost in familiar places, couldn’t remember the house number of the house, couldn’t recognize the appearance of family members, had difficulty speaking and reading, and even his temperament changed drastically.
On April 22, researchers at the Albert Einstein College of Medicine in New York, the United States, announced the design of an experimental drug designed to stimulate a special cell "garbage cleanup" mechanism, which can be used in animal models.
This drug-targeted system is called chaperone-mediated autophagy (CMA).
1.
1.
As people get older, the efficiency of CMA becomes lower and lower, thus increasing the risk of unwanted proteins accumulating into insoluble clumps and destroying cells.
▲Cells when CMA is working normally and cells lacking CMA (picture source: reference [3])
▲Cells when CMA is working normally and cells lacking CMA (picture source: reference [3])2.
2.
The researchers further observed the single-cell RNA sequencing data of brain neurons in patients with Alzheimer's disease and control healthy individuals.
"When people reach the age of 70 or 80, the activity of CMA usually decreases by about 30% compared to when they are younger.
3.
3.
"The production rate of LAMP2A has not changed in a person's life.
The researchers tested CA in two different mouse models of Alzheimer's disease.
At present, the research team has created a start-up biotechnology company called Selphagy Therapeutics, based on CA to further develop therapies for the treatment of Alzheimer's disease and other neurodegenerative diseases.
Reference materials:
Reference materials:[1] Experimental drug shows potential against Alzheimer's disease.
[1] Experimental drug shows potential against Alzheimer's disease.
Retrieved April 22, 2021, from
[2] Startup aims to treat Alzheimer's by invigorating neurons' garbage-disposal abilities.
Retrieved April 22, 2021, froms-specialized-garbage-cleaning-system
Retrieved April 22, 2021, froms-specialized-garbage-cleaning-system
[3] Bourdenx et al.
, (2021).
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
DOI: https://doi.
org/10.
1016/j.
cell.
2021.
03.
048
, (2021).
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
DOI: https://doi.
org/10.
1016/j.
cell.
2021.
03.
048
Note: This article aims to introduce the progress of medical and health research, not to recommend treatment options.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
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