Inspired by a poisonous snake! Ultra-fast painless patch syringe successfully debuted

The inspiration for venomous snake teeth: Capillary rapid penetrationsince the invention of subcutaneous injection, medicinal liquids and vaccines are generally given through needlesAlthough this method of injection has been a stable way to deliver drugs for hundreds of years, the pain, rejection and infection problems caused by needles are also not to be ignoredso, Professor Bae Won-kyu, from Chongshi University in South Korea, and Professor Jung-Hoon Jung of the National Ulsan Institute of Science and Technology (UNIST) of South Korea, "Open the Brain Hole", simulated the teeth of a poisonous snake, and developed a liquid drug delivery patch that effectively reduced the repulsion and pain of traditional injections and delivered polymer drugs to cells within 15 secondsDuvernoy glandular teeth secreting venom in the back teeth ofsnake Picture:Supplied Professor Bae Won-gyu said the design was inspired by the process by which venomisesWe know that some venomous snakes secrete venom through their teeth, while others release venom through the Duvernoy glands in the back teethThe release of adenotos is not only fast, but also free from external pressure, and works through capillary permeationSo, inspired by adenoid venom, the researchers designed a microneedle syringe with a groove at the top, which is like a venomous snake's back-groove tooth, and a groove filled with liquid is like a Duvernoy gland, under micro-pressure, the liquid naturally penetrates the subcutaneous cells through capillariesmini patch design: Get rid of needle fear
microneedle patches displayed on the human thumb deliver liquid drugs when slight pressure is applied to their surfacePhoto Source: Reference materials,paper to the end of the shallow, never know this matter to goUsing a semiconductor process, the researchers created a mini patch of about 1 square centimeter, filled with 100 microneedles about two or three hair-thick microneedles and up to six similar grooves, using the thumb to micropress the skin to penetrate the bodyPatch Act Image Source: ResourcesIt was found that, as expected, the patch, which is about 1 square centimeter, could inject 100?l of liquid into the skin in less than 1 second without the need for a complex dosing pump system Later, the researchers also tested the lidocanine agent or inactivated influenza virus on mouse and guinea pigs models It was found that the injection was completed in less than 5 seconds, and after penetration of the slightly longer drug, the animal model produced a corresponding immune response conclusion
Professor Bae Won-gyu and his team are excited about the results, saying: "By learning about nature's design of "ghostwork", we have not only perfected the shortage of existing subcutaneous syringes, but also addressed the rejection or pain caused by large needles and high pressure." In the future, we will conduct more clinical studies in large animal models and human volunteers, hoping to complete the development of this new syringe more quickly and to facilitate more doctors and patients references: .