Inspired by octopus, Chinese scholars develop noninvasive intra-eye gene drug delivery vector

Reporter son 11 was informed that, after nearly 8 years of research, Fudan University School of Pharmacy Professor Wei Gang research team in the field of non-invasive eye gene drug delivery research has made important progress, for the treatment of blinding chronic eye disease is of great significanceThe results have been published in nano Letters, an internationally renowned academic journalaccording to Wei Gang, the, hereditary retinopathy, retinoblastoma, age macular degeneration, diabetic retinopathy and other chronic under-eye diseases are the main causes of severe vision damage and even blindnessCurrently, the treatment of such diseases is done by using the drug, which will be approved for clinical use, and given by intra-eye injectionthe expert said, but because of the large molecular weight of genetic drugs, strong hydrophilic, the special protection mechanism of the eye will automatically prevent the drug from entering, so that it can not be absorbed in the eye, even small molecule drugs, its absorption rate is less than 5%, and the incidence of potential side effects is high, intra-eye inflammation, retinal cracking or shedding patients poor compliance risksTo change this, more than seven years ago, Wei Gang's team began a noninvasive drug delivery study within the eye, first designing a series of gene delivery systems for eye-droppingAccording to reports, in the research and development process, the research team was inspired by octopus, successfully built a similar octopus structure of flexible multi-"arm" permeatorThis is a genetic compound that acts as a carrier for the delivery of genetic drugs and maintains an efficient penetration of the eye absorption barrierit is learned that compared with the widely used market-based gene drug carrier, this new gene compound, the safety advantages are outstanding, and the preparation method is simple, stable, eye absorption effect is better, is expected to become a universal gene delivery carrier, can effectively promote the clinical transformation of gene therapy technology(Complete)