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Background: Programmed cell death protein-1 (PD-1) inhibitors are widely used to treat hepatocellular carcinoma (HCC)
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Hypothyroidism is usually related to this treatment, and the mechanism of this complication and its impact on the patient's prognosis are unclear
Methods: A retrospective analysis of the data of HCC patients receiving anti-PD -1 treatment from Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology from January 2018 to May 2020
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According to the evaluation of thyroid function, patients were divided into hypothyroidism group and non-hypothyroidism group
Figure: Survival analysis of patients receiving anti-PD-1 therapy
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(A) PFS in hypothyroidism and non-hypothyroidism patients; (B) PFS in hypothyroidism patients and non-hypothyroidism patients before immunotherapy; (C) PFS in TKI patients and non-TKI patients; (D) Using different PD-1 PFS of patients with inhibitors; (E) PFS stratified by liver function at first diagnosis; (F) PFS stratified by GGT before immunotherapyFigure: Survival analysis of patients receiving anti-PD-1 therapy
Table Cox regression analysis of progression-free survival of immunotherapy patients
Table Cox regression analysis of progression-free survival of immunotherapy patientsConclusion: In patients with liver cancer treated with PD-1 inhibitors, hypothyroidism is related to the prognosis, and the prognosis of patients with hypothyroidism is better than that of patients without hypothyroidism
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Hypothyroidism and Child-Pugh classification at first admission are independently related to the patient's prognosis
In patients with liver cancer treated with PD-1 inhibitors, hypothyroidism is related to the prognosis, and the prognosis of patients with hypothyroidism is better than that of patients without hypothyroidism
Xu L, Leng C, Chen L, Dong H, Chen Y, Chen X, Hypothyroidism is a Predictive Factor of Superior Anti-tumor Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.
Hypothyroidism is a Predictive Factor of Superior Anti-tumor Efficacy of PD-1 Inhibitors in Hepatocellular Carcinoma.
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