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Int J Clin Oncol: The efficacy of commercial CAR T cells in the treatment of relapsed/refractory aggressive B-cell lymphoma

 Last Update: 2021-06-10
 Source: Internet
 Author: User

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Two autologous anti-CD19 chimeric antigen receptor (CAR) T cells (axicabtagene ciloleucel[axi-cel] and tisagenlecleucel[tisa-cel]) have been approved for marketing in Europe for the treatment of relapsed/refractory (R/R) Diffuse large B-cell lymphoma (DLBCL).

Lymphoma

The researchers retrospectively collected data on 70 patients who received commercial CAR T cells at their institution from January 2018 to November 2019.

The results of multivariate analysis showed that the factors associated with poor PFS were the number of treatment lines (≥4) of CAR T cells (P = .

immunity

In summary, this analysis describes a study cohort of patients with R/R aggressive B-cell lymphoma using axi-cel and tisa-cel in the real world in Europe.

Original source:

Hideki Goto, Shinichi Makita, et al.

Efficacy and safety of tisagenlecleucel in Japanese adult patients with relapsed / refractory diffuse large B-cell lymphoma in this message

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