Int J Neuropsychopharmacol: Structural and functional abnormalities in the olfactory-related regions of the AD spectrum worsen with disease severity

Odor recognition (OI) dysfunction is an early marker that suggests an Alzheimer's disease (AD) pathology and predicts the development of dementia, with the advantage
of non-invasiveness, cost-effectiveness, and high patient compliance.

Odor recognition (OI) dysfunction is an early marker of Alzheimer's disease (AD), but it is unclear how the olfactory-related region transitions from the stages of subjective cognitive decline (SCD) and mild cognitive impairment (MCI) to AD dementia
.

Ben Chen et al.

The study hypothesized that structural and functional abnormalities in the olfactory-related regions present in SCD patients deepened in patients with MCI and AD, and that these abnormalities mediated the relationship between
OI and cognitive function.

The study recruited 269 people
.

Figure 1.

From SCD, MCI to AD groups, the GMV reduction of the olfactory related regions, the increase of low-frequency amplitude, the increase of ReHo, and the decrease of FC are becoming more and more serious, and only the degree of GMV reduction of hippocampal and caudal nuclei can clearly distinguish between the three groups
.

Figure 2.

Figure 3: FC of olfactory associated brain regions
in the AD, MCI, SCD and NC groups was compared.

2.

Table 4.

Figure 4: Abnormalities in olfactory-related brain regions mediate the relationship between
OI and overall cognition.

3.

Structural and functional abnormalities in olfactory-related regions appear early in SCD and deepen
in the AD spectrum with disease severity.

Source of the original text

Chen B, Wang Q, Zhong X, et al.