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Int J Radiat Oncol Biol Phys: Failure to follow the guidelines in radiotherapy will reduce the survival rate of patients with locally advanced pancreatic cancer!

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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Pancreatic cancer is still one of the leading causes of cancer-related deaths.

Pancreatic cancer

The main results of the LAP07 multicenter randomized study (international randomized phase 3 trial) showed that in patients with locally advanced pancreatic cancer that were controlled 4 months after induction chemotherapy, there was no significant difference in the overall survival rate of patients with chemotherapy and continuous chemotherapy .

This article mainly reports the results of the secondary objective analysis of the LAP07 study: whether failure to follow the radiotherapy (RT) guidelines will affect the survival rate and toxic side effects of patients .

Will failure to follow the radiotherapy (RT) guidelines affect the survival rate and side effects of patients?

The assessment includes detailed written RT guidelines.

Guideline compliance

Of the 57 cases that underwent baseline assessment, 26% were classified as PP, 60% were MiD, and 14% were MaD.

Among the 442 patients included in the analysis, 133 patients were randomly assigned to the radiotherapy and chemotherapy group.

The impact of guideline compliance deviations on survival prognosis

The impact of guideline compliance deviations on survival prognosis The impact of guideline compliance deviations on survival prognosis

The most common deviation scheme is uneven dose distribution .

The most common deviation plan is uneven dose distribution.

The MaD level is related to the trend of the worst survival.

Original source:

Giraud Paul, Racadot Séverine, Vernerey Dewi et al.

org/10.
1016/j.
ijrobp.
2021.
01.
055" target="_blank" rel="noopener">Investigation of Relation of Radiation Therapy Quality With Toxicity and Survival in LAP07 Phase 3 Trial for Locally Advanced Pancreatic Carcinoma in this message

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