Int J Urol: Investigation of predictive factors for postoperative recurrence of non-metastatic pT3a renal cell carcinoma

Radical nephrectomy and partial nephrectomy are radical treatments for non-metastatic RCC
.

The recurrence rate of patients with radical surgery is about 30%, and close follow-up is required for patients with high risk of recurrence

Recently, researchers from Japan published an article in "Int J Urol" to analyze the effects of extrarenal tumor expansion patterns and other pathological factors on postoperative recurrence of patients with non-metastatic pT3a renal cell carcinoma
.

The effect of extrarenal tumor expansion pattern and other pathological factors on postoperative recurrence of patients with non-metastatic pT3a renal cell carcinoma

Researchers investigated 587 non-metastatic renal cell carcinoma patients who underwent radical surgery at Kansai Medical University Hospital in Osaka, Japan between 2006 and 2017
.

A subgroup of 114 patients with the main histological type of pT3a was screened, including 93 clear cell renal cell carcinoma patients (81.

Among 114 patients with pT3a renal cell carcinoma, 42 patients (36.
8%) experienced recurrence
.

Multivariate analysis showed that perrenal fat infiltration (hazard ratio 2.

RFS stratification of pT3a patients

RFS stratification of pT3a patients

In summary, in patients with pT3a renal cell carcinoma, perirenal fat infiltration, sarcoma or striated muscle, and necrosis are independent factors predicting recurrence-free survival
.

Patients with more than two of these predictors have a poorer prognosis

In patients with pT3a renal cell carcinoma, perirenal fat infiltration, sarcoma or striated muscle, and necrosis are independent factors predicting recurrence-free survival.

Original source:

Haruyuki Ohsugi, Chisato Ohe, Takashi Yoshida et al.

Predictors of postoperative recurrence in patients with non-metastatic pT3a renal cell carcinoma

 

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