Int Urol Nephrol: Oral probiotics do not change the microbiome of the female urinary system.

Probiotics can reduce the risk of urinary tract infections by preventing the implantation of urinary pathogens.
the double-blind randomized controlled trial was designed to determine changes in the proportion of lower urinary pathogens in the lower urinary tract caused by oral probiotics: lactic acid bacteria (U/L).
study recruited volunteers for healthy women before menoanth.
participants were provided with three months of daily urination time, including three phases of the trial: 1 - baseline, 2 - intervention, 3 - flushing.
participants were randomly accepted with oral probiotics (L.L. GR-1 and Lactobacillus Aloe RC-14) with a placebo.
result is the U/L ratio of daily emptying of urine as determined by the enhanced urine culture method.
analysis ratio using t-test and using independent generalized linear mixing effect model (GLMM) to analyze microbiome diversity.
results, 481 samples of 7 female participants with an average age of 29.1 years (±5.3 years) were analyzed (probiotic n s 4; placebo n s 3).
no adverse events have been reported.
the average U/L ratio was similar in the placebo group and the probiotic group, there was no difference between the placebo group and the probiotic group in stages 1-3 (p s 0.90, p s 0.58 and p s 0.72, respectively).
have not been identified in the excreted urine.
there was no change between groups in terms of microbiome diversity.
, the results show that for young healthy women, oral probiotics do not affect the U/L ratio.
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