Inter-α inhibitor protein reduces ischemic stroke injury

According to research by preclinical researchers at the University of Texas Health Science Center in Houston (UTHealth), adding a naturally occurring protein family that can inhibit inflammation in the body has been proven to effectively reduce the damage caused by ischemic stroke

Interalpha inhibitor proteins (IAIP) is a family of structurally related proteins, which are mainly produced in the liver and found at high concentrations in plasma, which have a wide range of anti-inflammatory activities

"Inter-α inhibitor proteins (IAIPs) are a family of endogenous plasma and extracellular matrix molecules.

"In this study, we first assessed the clinical relevance of IAIPs in stroke, and then tested the therapeutic effects of exogenous IAIPs in several experimental stroke models

"Through targeted gene expression analysis, we identified the complement-activated receptor C5aR1, which is highly inhibited in the blood and brain of iaip-treated animals

Dr.

"To test the clinical relevance of these proteins, we first studied the changes in IAIP, using blood and brain samples from stroke patients

Ischemic stroke accounts for 80% to 85% of all strokes and is caused by blockage of the arteries that supply blood to the brain

Researchers found that after a stroke, the level of IAIP naturally produced in mice and humans decreases

Importantly, even if IAIP is delayed 4.

The combination of IAIP and tissue plasminogen activator (t-PA) is also the most effective in mice.