Interaction between Ginseng and chemicals

2015-12-10 classification: efficacy and action: 0 people commented that ginseng is the qianzao root of Panax ginseng C.A mey, a plant of Acanthopanax family It is used to supplement energy, reduce fatigue and weakness, treat sexual hypofunction and anxiety, fight hypertension, antioxidation, reduce "Zha fat", enhance cognitive ability, fight cancer, etc The main pharmacological active component is ginsenoside A large number of in vivo and in vitro studies show that ginseng can regulate many CYP isoenzymes involved in warfarin metabolism Ginsenoside Rd has weak inhibitory activity on CYP3A4, CYP2D6, CYP2C19 and CYP2C9 recombinants, while ginsenoside Re and RF can enhance the activities of CYP2C9 and CYP3A4 Studies on rats showed that Standard red ginseng saponin can inhibit the activity of p-nitrophenol hydroxylase CYP2E1 in a dose-dependent mode It was found that nifedipine, the substrate of CYP3A4, was significantly increased after taking ginseng for 18 days, which indicated that ginseng could inhibit CYP3A4 enzyme activity In vitro study showed that ginseng competitively combined with P-gp expression.