Interferon regulatory factor research has made progress.

Acquired immunity appears in the early stages of vertebrate differentiation, how does it appear, and how does it engage with congenital immunity and work together? The available scientific data cannot answer this question perfectly.
in the early stages of acquired immunity, some immune genes have undergone a corresponding significant evolution, acting within the two immune systems, communicating between the two.
the study of this kind of immune gene can not only deepen the understanding of the gene itself, but also provide new ideas and ideas to explain the above problems.
interferon regulator factor (IRF) is one such gene.
previous research on the development and functional differentiation of The IRF system, due to the lack of key data, can not give a comprehensive perspective.
the research group of He Weiping, a researcher at the Institute of Aquatic Biology of the Chinese Academy of Sciences, has a deep erstiny accumulation in The Research of IRF, and the genomes or transcription groups of some ancient fish and seven eels that have recently been sequenced provide key support for this study.
the subject group identified 148 IRFes in a massive genome or transcription group of 11 vertebrates and 4 protozoa animals using similarity searches.
analysis of the reconstruction of the system's development tree and linear tracking corrects previous conclusions, suggesting that the vertebrate's IRF was produced from three ancestral genes instead of four by doubling the second genome and later copying.
thus, in the later analysis, the IRF family is divided into three groups. The results of the analysis of
expression patterns not only showed that the expression spectrum of the iRF members showed a differentiation trend, but also suggested that some members exercised functions other than immunity.
natural selection stress analysis shows that, although most vertebrate SEFs are positively selected, one member of each group was found to have undergone a purification selection, suggesting that the member may have assumed the ancestral function of the group, thus protecting its group members from the pressure of the purification selection and evolving new functions.
a combination of previous research on the regulatory network of IRF, and the idea that new genes regulate existing gene networks, the study argues that interferons (Interferon, IFN) in the own jaws, as new genes are involved in the then-existing IRF regulatory network, introducing new gene interactions and selection pressures, which have led to the complex and innovative evolution of the family;
research has been supported by the National Natural Science Foundation of China.
related papers are based on ancient co-authors and the sio-os s theoon regulatory factors of the sops of the forsys for the insights into the evolution of the immune immune systems, published online in Thedevelopmental and Comparative
.