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Intermittent fasting to lose weight? Fat says "no" |
In a mouse study, Australian researchers mapped the changes in fat tissue during intermittent fasting (every other day), and unexpectedly found that certain types of fat are more "resistant" to weight loss.
Using advanced equipment, researchers at the University of Sydney have discovered that the fat around the human stomach will accumulate into a "protruding belly".
The research team led by the Charles Perkins Centre at the University of Sydney and Dr.
The types of fat that have changed include visceral fat and subcutaneous fat.
"Although most people think that all adipose tissue is the same, in fact, the location of adipose tissue is very different.
During fasting, adipose tissue provides energy to other parts of the body by releasing fatty acid molecules.
Larance said it is possible that the history of repeated fasting triggered the preservation signaling pathway in visceral fat.
Before conducting human studies, the use of mouse models is a useful simulation method.
The research team tested more than 8,500 proteins in fatty deposits and used a technique called proteomics to create a catalog of changes that occurred during intermittent fasting.
The results of the study provide a rich source of data and help to more comprehensively describe the internal workings of adipose tissue.
However, Larance reminded that it should be noted that the results of this intermittent fasting study may not be applicable to other diets, such as the 5:2 diet (fasting for 2 days every 7 days) or calorie restriction.
This result laid the foundation for future research.
Future studies in mice and humans may reveal the mechanism by which this resistance occurs, as well as what type of diet and other interventions may be the most effective solution to the problem of abdominal fat.
Related paper information: org/10.
org/10.
1016/j.
celrep.
2021.
108804" target="_blank">https://doi.
org/10.
1016/j.
celrep.
2021.
108804