International Digital Liver Congress: Changing gut bacteria can reduce cravings for alcohol, new research suggests.

Read: A new preliminary study shows the importance of gut bacteria in reducing the burden of alcohol-related liver disease and liver cancer.
, August 27, 2020 /XINHUA/ -- A new preliminary study presented at the 2020 International Conference on Digital Liver ™ 2020 demonstrates the importance of gut microbiotics in reducing the burden of alcohol-related liver disease and liver cancer.
study looked primarily at whether transferring fecal bacteria from healthy people to patients (FMT) as a first step in a larger trial could reduce alcohol cravings.
in a randomized, double-blind placebo-controlled preliminary clinical trial, 20 patients with alcohol use disorders who had previously tried multiple alcohol withdrawal options but were unsuccessful had a fecal transplant or a placebo.
15 days after treatment, fecal transplants showed signs of reducing alcohol cravings, as well as positive disease effects on the overall and psychosocial levels.
, compared with baseline patients, the level of bacterial diversity was significantly improved in patients receiving fecal transplants.
imbalance above the intestinal bacteriosty has been linked to alcoholic liver disease, and this study raises the possibility of using intestinal bacteriosage management to improve patient treatment.
in the case of chronic alcohol use, reactive oxygen produced by alcohol metabolism can lead to chronic intestinal inflammation, which can improve intestinal permeability and alter the composition of the bacteria.
improvement in intestinal permeability is believed to cause gut bacterial DNA and endotoxins to be transferred to the liver.
the latter is thought to trigger inflammatory path path path roads associated with the development of liver disease, including cancer. Dr Jasmohan Bajaj, of McGuire Medical Center in Virginia and the publisher of the
ILC study, commented: "The use of manure transplants is safe and shows a positive impact on reducing short-term alcohol cravings and improving the psychosocial quality of life in patients with cirrhosis and alcohol use disorders.
The relatively abundant bacteria found in patients with higher levels of diversity that produce short-chain fatty acids after a fecal transplant suggests that changing the axis of the intestine is a potential way to alleviate alcohol use disorders in patients with cirrhosis.
Professor Luca Valenti, a member of the Scientific Committee of the European Society for the Study of the Liver (EASL) from the University of Milan in Italy, said: "Understanding the interaction of human and bacterial genomes on health and disease is one of the important areas in which progress has been made over the past few years.
study provides the basis for exploring this new knowledge for the treatment of liver disease.
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