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    Home > Active Ingredient News > Immunology News > Interpretation of important research results published by Chinese scientists on CNS! (August-October 2020)

    Interpretation of important research results published by Chinese scientists on CNS! (August-October 2020)

    • Last Update: 2020-11-09
    • Source: Internet
    • Author: User
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    .5 Nat Biomed Engine: Heavy! Chinese scientists have developed a new precision therapeutic leukemia vaccine doi:10.1038/s41551-020-00624-6 In a recent study published in the international journal Nature Biomedical Engineering, scientists from the Institute of Process Engineering of the Chinese Academy of Sciences and the Pearl River Hospital of Southern Medical University are expected to develop a precision therapeutic leukemia vaccine.
    researchers say exploring new leukemia antigens and using FDA-approved talent to build appropriate transportation administration systems is an important strategy for developing leukemia vaccines for clinical use.
    Now researchers have developed a therapeutic vaccine against leukemia that uses a self-healing poly lactic acid microcapsules to include a new table peptide and PD-1 antibody, although it is now possible to treat leukemia with a vaccine, but its therapeutic performance is still far from clinically expected 'Our clinical results show that EPS8 and PD-1/PD-L1 in leukemia patients have higher levels of expression, which may be used as a new type of leukemia antigen and checkpoint target to help develop a new leukemia vaccine, respectively,' said researcher Li Yuhua.
    image Source: Nature: Chinese scientists discover new coronavirus S-RBD vaccine can induce protective immune response doi:10.1038/s41586-020-25 Now, scientists have confirmed that THES-CoV and MERS-CoV's RBD contains major structurally dependent neutrality and cousins, and is able to produce powerful neutral antibodies in immune animals, thus promising vaccine development targets.
    in a new study, researchers from research institutions such as Sichuan University of China, Macau University of Science and Technology and Beijing Concord Medical College built a recombinant vaccine consisting of the S protein's bind binding domain (RBD) amino acid residue 319-545. (S-RBD vaccine) and found that the recombinant vaccine was performed in mice, rabbits, and non-human primate rhesus monkeys within 7 or 14 days of a single dose of the recombinant vaccine inducing an effective functional antibody response, the study was published in the journal Nature.
    serum from these vaccinated animals blocks the binding of RBD to ACE2 expressed on the cell surface and infects SARS-CoV-2 prosthetic and SARS-CoV-2 live viruses in inosometic energy.
    important, in vivo, the recombination vaccine also protects non-human primates from SARS-CoV-2 attacks.
    also found elevated levels of RBD-specific antibodies in the serum of PATIENT-19 patients.
    several immune pathways and CD4-plus T cells were involved in the antibody response induced by this recombinant vaccine.
    these findings highlight the importance of RBD domains in SARS-CoV-2 vaccine design and provide a theoretical basis for the development of protective vaccines that induce the production of antibodies against RBD domains.
    7 (Xinhua) -- Researchers from China University of Science and Technology, Guangzhou University, Sichuan University and Heidelberg University in Germany have come up with new insights into this incredible ability in a new study by Chinese scientists who have revealed the mechanisms by which plant stem cells are protected from various virus infections. CMV) inoculated on the thale cress plant and observed what had happened.
    when the cucumber leaf virus spread to SAM, they noticed that the virus stopped before it reached an area that expressed WUSCHEL.
    looked closely at the distribution of the regulated protein WUSCHEL in this region, they found that more WUSCHEL appeared where the virus was trying to gain a foothold after vaccination.
    As an extremely important protein, WUSCHEL plays a key regulatory role in determining the fate of stem cells in the early stages of plant embryo development, while also overseeing SAM, keeping them undifferentiated and determining what kind of daughter cells they produce.
    : Chinese scientists have discovered that using small molecule ACA to target TGF-β signaling paths inhibits a range of viruses, including the new coronavirus, HIV and A-flu virus, doi:10.1126/sciadv.a In a new study, researchers from the University of Hong Kong, Mary's Hospital and Hainan Medical College identified a small molecule that inhibits a variety of different viruses, including SARS-CoV-2, in tissue cultures and mice by targeting TGF-β signaling path paths.
    findings provide a potential target for the development of broad-spectrum antiviral drugs by identifying a host cell pathway on which multiple viruses can successfully infect, the findings of which were recently published in the journal Science Advances.
    New viruses, including SARS-CoV-2, HIV, Zika and avian influenza A viruses, can pose unique challenges for scientists because the interactions between viruses and their hosts often drive evolutionary changes that diversify the responses of viruses and hosts.
    to stay ahead of the arms race, scientists are looking for many of the evolutionary conservative mechanisms common to host-virus interactions to provide a comprehensive solution.
    To see if the TGF-β signaling path is a target for antiviral therapies against many viruses, Shuofeng Yuan, a postdoctoral researcher in the Department of Microbiology at the University of Hong Kong, and his colleagues screened previously discovered inhibitors for the signaling path.
    they found a compound called the small molecule N(p-Amylcinnamoyl) anthranilic acid (ACA), which successfully suppressed influenza A virus, MERS-CoV, SARS-CoV-2, HIV, adenovirus, and two small RNA viruses (picornavirus) in tissue cultures and mice.
    -9) Science: Chinese scientists reveal that filter-assisted T-cells expressing SOSTDC1 promote follicular regulation T-cell differentiation doi:10.1126/science.aba6652 filter-assisted T-cells (T-follic helper, cell, TFH) is a CD4-plus T cell that promotes the production of B-cell antibodies and B-cell memory response in the birth center of the lymphatic organ.
    these activities are also restricted by follicular helper cells (TFR).
    the center reaction can enhance TFR
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