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    Home > Active Ingredient News > Study of Nervous System > Interpretation of Nature Sub-Journal: Scientists have discovered that humans suffer from multiple diseases or have common...

    Interpretation of Nature Sub-Journal: Scientists have discovered that humans suffer from multiple diseases or have common...

    • Last Update: 2021-05-03
    • Source: Internet
    • Author: User
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    Recently, in a research report titled "Plasma metabolites to profile pathways in noncommunicable disease multimorbidity" published in the international journal Nature Medicine, scientists from the University of Cambridge and other institutions have identified through research that it can increase individual suffering from one or more diseases.
    This is a key risk factor for the possibility of non-communicable diseases, such as cardiovascular disease, cancer, chronic respiratory disease and diabetes.

    In the article, researchers conducted a study of more than 11,000 people and found that people with multiple diseases often have potential biological associations in their bodies, rather than accidental reasons.
    Multimorbidity is defined as two or more.
    Diseases that have long-term effects on the health of the body are an increasingly serious public health challenge facing mankind today.
    In the United Kingdom, approximately two-thirds of people aged 65 and over suffer from polymorbidity, whose impact on the quality of life of the population exceeds the cumulative burden of each disease.
    Understanding that these diseases do not occur randomly, but through a common mechanism, may be expected to help researchers develop preventive strategies and improve the current medical service system.

    Researcher Claudia Langenberg said that we analyzed the levels of 1014 metabolites in the body of more than 11,000 participants in the European Cancer Prospective Cohort Study (EPIC).
    These metabolites refer to the body such as sugars, vitamins or Circulating small molecules such as lipids can objectively reflect the influence and interaction of the body's genetic characteristics, lifestyle, environment, medical conditions, and gut microbiome on the body's physiology.

    By integrating all existing data to obtain a holistic view, researchers can identify and record the associations between these metabolites and 27 different non-communicable diseases, which often exist in multiple diseases.
    The researchers found , Almost half of the metabolites are related to at least one of the 27 diseases.
    Two-thirds of disease-related metabolites are shared by many diseases.
    Therefore, with the occurrence of multiple diseases, the increase in plasma levels of carbohydrate N-acetylneuraminic acid in the body may be related to the high risk of 14 diseases.

    The researchers then analyzed the associations between more than 50 characteristics in the participants’ bodies, including waist-to-hip ratio to smoking behavior, etc.
    , with the aim of determining the profound changes in small molecules in the body, thereby helping to explain the effects of common risk factors on the risk of diseases.
    Impact; the findings of this article highlight poor kidney and liver health, blood sugar and blood lipids, gut microbial diversity and lifestyle factors or potential prevention or treatment targets, which can help reduce the effects of multiple diseases Health burden.
    Researcher Dr.
    Claudia Langenberg said that an in-depth understanding of molecular processes can not only help improve the treatment of diseases, but also help identify individuals at risk as early as possible; for example, we found that compared with current standard clinical trials, the measured Many of the metabolites may serve as good predictors of the risk of kidney-related diseases in the future.
    The reason why the study in this article can go smoothly is that researchers can use samples stored for up to 20 years before the onset of a patient’s disease to determine the concentration of hundreds of small molecules in their blood samples, as well as the electronic health data of more than 11,000 participants.
    research.

    Researcher Maik Pietzner added that we found that two-thirds of small molecules may be related to at least two seemingly unrelated diseases.
    This is strongly related to the disease-centric approach that is still common in biomedical research.
    People usually don’t suffer from only one disease, and researchers can deeply understand the biological processes that occur behind it, and the development of new therapies for two or more diseases may provide patients with a more consistent approach.
    The benefits and avoid the risk of other diseases.
    Finally, the researchers said that the results of this article may help scientists to understand the biochemical pathways involved in the occurrence of multiple diseases.
    This is not only essential for the diagnosis and prediction of early diseases, but also identifying these metabolic footprints is also expected to help.
    In the future, scientists will develop new treatment methods; most importantly, in this study, researchers have clarified the possible associations between seemingly unrelated diseases, which provides new ideas and foundations for later in-depth research.

    Reference materials:

    Reference materials:

    [1] Pietzner, M.
    , Stewart, ID, Raffler, J.
    et al.
    Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.
    Nat Med 27, 471–479 (2021).
    doi: 10.
    1038/s41591-021-01266- 0

    [1] Pietzner, M.
    , Stewart, ID, Raffler, J.
    et al.
    Plasma metabolites to profile pathways in noncommunicable disease multimorbidity.
    Nat Med 27, 471–479 (2021).
    doi: 10.
    1038/s41591-021-01266- 0

    【2】New study finds shared origins for individual chronic diseases in multimorbidity

    【2】New study finds shared origins for individual chronic diseases in multimorbidity

    by UK Research and Innovation

    by UK Research and Innovation

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