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    Home > Biochemistry News > Biotechnology News > Intestinal bacteria are no match for 'seduction' and alliance with a high-fat diet to resist insulin production

    Intestinal bacteria are no match for 'seduction' and alliance with a high-fat diet to resist insulin production

    • Last Update: 2020-06-08
    • Source: Internet
    • Author: User
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    DOI: 10.1038/s41467-019-11370-yToronto General Hospital Institute and University Health Network (UHN) pathologist DrDan Winer and his team found that a high-fat diet is key to weakening the immune system of the gutStudies have shown that a high-fat diet affects B cells in the immune system in the gut sinof strains of mice and produces a protein called IgAIt is worth noting that IgA is a key protein for regulating insulin resistance associated with obesityIgA protein is a defensea growing body of research in recent years has found that when people are obese, our immune system often responds to bacterial components that cause inflammation through "leakage" of intestinal tissueIn turn, inflammation can drive insulin resistance and make people susceptible to diabetesthe researchers fed mice with outIgA antibodies for 12-14 weeks on a high-fat diet and found that blood sugar levels in mice lacking IgA antibodies deteriorated sharply compared to normal miceAt the same time, the researchers transplanted the gut bacteria from mice with out IgA antibodies to normal mice and found that normal mice had some diseases, further suggesting that IgA could regulate the amount of harmful bacteria in the gutHelen Luck, lead author of thestudy, said: "We found that low-level B cells in the gut during obesity can produce an antibody called IgAIgA, which is naturally produced by our bodies, is essential for regulating gut bacteriaIt serves as a defense mechanism that helps to moderate potentially dangerous bacteria when people consume too much fat to break the digestive balanceIgA protein defection
    to understand how a high-fat diet causes diabetes, the researchers learned more about gene expression in miceThe study found that colon tissue in mice on a high-fat diet showed a significant decrease in the expression of the Aldh1a1 gene This suggests that a high-fat diet alters the immune regulation mechanism sproducing by IgA While IgA may play a key role in the balance of glucose throughout the body, the lack of IgA can lead to a deterioration of glucose stability More importantly, changes in IgA's immunomodulation mechanism increase inflammation in the body in the UHN Bariatric Surgery Study led by Dr Johane Allard and Dr Herbert Gaisano, the researchers found that igA levels in the feces of patients increased shortly after bariatric surgery, indicating the importance of IgA and the intestinal immune system for obese patients metformin re-appears metformin is one of the most commonly used treatments for type 2 diabetes, but its mechanism of action is not fully clear The researchers believe that the intestinal flora may be the main mechanism of action for metformin The researchers observed metformin effectively stops the decline of the IgA protein in mice fed on a previously high-fat diet "If we can enhance IgA, then we can control the type of bacteria in the gut, " "Looking ahead, this work could be a new intestinal immune biomarker or a basis for treating obesity and its complications, such as insulin resistance and type 2 diabetes." "
    1' New study links high-fat diet and gut bacteria to insulin resistance s Intestinal flora unites high-fat diet to resist insulin
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