Intestinal microbes may prevent sepsis.

Perhaps the fight against sepsis can be helped in a surprising way: gut bacteria.
researchers have found that increasing the immune protein A antibody in the blood of mice prevents bacterial invasions that cause sepsis.
, the paper was published in the journal Cell-Host and Microbiology.
previous studies have linked immune protein A responses to gut bacteria and detected the immune protein A-specific component of gut bacteria in the serum of mice.
, people with immunoprotein A-defects are more likely to develop sepsis.
However, the link between the two observations is still pending.
researchers have found that immunoprotein M antibodies react quickly to bacteria in the blood of sepsis patients, while gut microbes trigger an immune protein G antibody reaction that prevents bacterial infection.
, the researchers wanted to find out whether gut microbes could trigger an immune protein A response to prevent sepsis. "The serum immunoprotein A and immunoprotein G antibodies may play a similar role to those of the natural immune protein M antibody, which provides a non-inflammatory mechanism to prevent invading bacteria," said Joel Wilmore of the University of Pennsylvania,
lead author of the paper.
" To study this possibility, the team of David Allman of the University of Pennsylvania exposed mice to a unique and natural microbiome, including several morphates that raise seismoprotein A levels in the blood.
when they transferred blood that lacked immunoprotein A to mice with sepsis, most of the mice died within two days.
, mice that received blood rich in immunoprotein A survived longer.
these results suggest that symbiotic microorganisms can have a significant impact on immune protein A levels in the blood, thus preventing bacterial sepsis.
based on these findings, the researchers plan to further analyze the protective effect sepsis of immunoproteins and explore new ways to treat human diseases using the properties of these antibodies.
at the same time, the researchers urged people not to overread the new findings. "There's a limitation in this study because everyone or animal has some what's unique about the microbes in the animal, and our study was conducted in an animal laboratory environment at the University of Pennsylvania," said allman, a
.
When immunoprotein A protects mice in the study, we should not assume that it can replace the standard treatment provided to patients in clinical settings.
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