Intra-epidermal Nerve Fibers Density and Nociception in EPO-Treated Type 1 Diabetic Rats with Peripheral Neuropathy
Last Update: 2020-12-19
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Small-diameter nerve fibers, which subserve nociception, can be affected early in peripheral neuropathies, although theirinjury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliabletool to examine nonmyelinated nerve fibers, as assessed by the quantification of intra-epidermal nerve fiber (IENF) densitynot only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacysuch as erythropoietin (EPO) treatment.
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