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It is understood that certain types of bacteria can be nearly infrared (NIR) absorbents delivered to the tumor for photothermal ablation.
, however, light therapy or photoimmune therapy using bacteria alone is not currently possible without the addition of other therapeutic agents or nanoparticles.
August 14th, a study published by Science Advances broke through the bottleneck and proposed a photoimmune therapy that uses bacteria entirely.
A team of researchers from Suzhou University found that the detoxifying salmonella proliferates in various types of solid tumors after intravenous injection, causing inflammation that triggers thrombosis in infected tumors by destroying the blood vessels of the tumor, thus helping to effectively ablate the tumor.
, bacteria-triggered photothermal therapy can induce an effective anti-tumor immune response.
DOI: 10.1126/sciadv.aba3546 Specifically, the researchers first determined the distribution of detoxifying salmonella in mice.
found that 72 hours after the injection, the bacteria had gradually been removed from major organs such as the heart, liver, spleen, kidneys and lungs.
contrast, the units of formation (CFUs) in tumors increase exponentially over time.
, the researchers tracked the bacteria's long-term behavior in normal organs in mice and found that after 30 days, few bacterial infections were found in the mice's organs.
next step, researchers need to determine the safety of the detoxifying salmonella.
results from a blood test showed that acute inflammation caused by the detoxifying salmonella was toned in mice and could recover within a week without chronic toxicity.
of bacteria in mice with post-intravenous hormone tumor and healthy mice showed that detoxifying salmonella would accumulate in tumors with high biosecurity specificity after injection at a test dose.
safety was determined, the researchers went on to examine the effects of detoxifying salmonella on tumors.
found that significant vascular dissolution and thrombosis were observed in tumor slices in mice injected with bacteria.
addition, the hemoglobin content of the tumor site increased significantly after the bacteria were injected.
results suggest that the implantation of detoxifying salmonella in tumors can trigger tumor-specific thrombosis by destroying tumor blood vessels.
and this effect leads to strong tumor-specific near-infrared absorption, which enables effective photothermal ablation of tumors.
tumor photothermal ablation triggered by bacteria, the researchers looked at the immune response of bacteria-triggered photothermal therapy to ablation of tumors in mice.
they found that the bacteria acted as immune stimulators, enhancing a systemic anti-tumor immune response triggered by tumor-related antigens produced by photothermal therapy to ablation of tumors.
bacteria-induced photothermal immunotherapy In addition, with the help of anti-CTLA-4 checkpoint blocking therapy, bacterial-based photothermal therapy can effectively inhibit the growth of distant tumors and spontaneous tumor metastasis, while providing long-term immune memory effects, thereby protecting mice from re-caused tumors.
researchers stress that these effects of typhoid salmonella in detoxifying mice will make it a promising biologic agent in cancer co-treatment.
even more exciting is that salmonella, which reduces typhoid fever in mice, has been clinically tested, making this bacteria-based treatment easy to convert clinically.
: (1) DOI: 10.1126/sciadv.aba3546.