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1.
Antimicrobial peptides are natural immune substances produced by the constituent expression or induction of animals and plants in the body, and are an important part of
1.
tachyplesins and polyphemus (collectively referred to as peregrine) are a group of small molecule polypeptides present in the small particles of the blood lymph granule cells of the horseshoe, consisting of 17 to 18 amino acids, and the relative molecular mass is about 2.
3.
In addition to the above immune active factors
- Iwanaga S.
The molecular basis of innate immunity in the horseshoe crab[J] .
Curr Opin Immunol, 2002, 14(1):87 - 95. - Matsuzaki K.
Why and how are peptide - lipid interactions utilized for self - defense? Magainins and tachyplesins as archetypes[J] .
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Membrane permeabilization mechanisms of a cyclic antimicrobial peptide tachyplesin I, and its linear analog[J] .
Biochemistry , 1997, 36(32):9 799 - 9 806. - Chen Y X, Xu X M, Hong S G, et al .
RGD - tachyplesin inhibits tumor growth[J] .
Cancer Res, 2001, 61(6):2 434 - 2 438. - Suetake T, Tsuda S, Kawabata S, et al .
Chitin - binding proteins in invertebrates and plants comprise a common chitin - binding structural motif[J] .
J Biol Chem, 2000, 275(24):17 929 - 17 932. - Osaki T, Omotezako M, Nagayama R, et al .
Horseshoe crab hemoyte - derived antimicrobial polypeptides, tachystatins, with sequence similarity to spider neurotoxins [J] .
J Biol Chem, 1999, 274(37):26 172 - 2 6178. - Fujitani N, Kawabata S , Osaki T, et al .
Structure of the antimicrobial peptide tachystatin A[J] .
J Biol Chem, 2002, 277(26):23 651 - 23 657. - Kawabata S, Saito T, Saeki K, et al .
cDNA cloning , tissue distribution, and subcellular localization of horseshoe crab big defensin[J] .
Biol Chem, 1997, 378( 3 - 4):289 - 292. - Iwanaga S, Kawabata S, Muta T.
New types of clotting factors and defense molecules found in horseshoe crab hemolymph:their structure and functions[J] .
J Biochem, 1998, 123(1):1 - 15.