Introduction to the efficacy and effect of chemical APIs on acetaminophen powder

The chemical API acetaminophen is 4'-hydroxyacetanilide
.

According to the calculation of dried products, the C8H9NO2 containing should be 98.
0% to 102.
0%.
【Properties】This product is white crystalline or crystalline powder; Odorless
.

Soluble in hot water or ethanol, soluble in acetone, slightly soluble
in water.

Acetaminophen is antipyretic and analgesic drugs, the main role is antipyretic and analgesic, can be used for various causes of fever, this drug only for the body temperature is higher than normal fever to play a depyretic effect, the normal body temperature and body temperature is lower than normal is no effect, in addition, this drug can be used for a variety of pain, such as cold fever, trauma and other headaches, joint pain, limb pain, muscle pain, etc.
, but for gastrointestinal colic is no effect
。
【Category】Antipyretic analgesic, nonsteroidal anti-inflammatory drugs
.

【Storage】Sealed and stored
.

【Preparations】(1) Acetaminophen tablets (2) acetaminophen chewable tablets (3) acetaminophen effervescent tablets (4) acetaminophen injection (5) acetaminophen suppositories (6) acetaminophen capsules (7) acetaminophen granules (8) acetaminophen drops (9) acetaminophen gel acetaminophen mainly has a fever-reducing effect, the mechanism of action is to regulate the nerves, so that peripheral capillaries expand and sweat, In this way, the effect of reducing fever is achieved
.

In addition to the cooling effect, it also has a certain analgesic effect, this type of drugs are antipyretic and analgesic, such as headaches caused by colds, joint pain, migraines or wound pain after surgery can also take acetaminophen to achieve pain relief
.

To know its mechanism of action, so when children take it, they should pay attention to the following points: First, because children often choose acetaminophen to reduce fever, so after taking it, it is necessary to give him appropriate warm water to maintain normal blood circulation
.

Second, to control the interval and dosage, each time the body temperature exceeds 38.
5 ° C, you need to give him acetaminophen, but the interval between the two times is at least four hours, do not give him too frequently
.

Third, in accordance with the recommended dose given on the instructions to the child to take, do not overdoses, because excessive use may cause the child to sweat too much, will lead to his prostration, or shock, urine loss and other symptoms, so to strictly follow the dosage on the instructions, while taking warm water
after taking.

The side effects of acetaminophen tablets include allergic reactions, liver damage, etc.
, as follows: 1.
Allergic reactions: can cause skin itching, rash, urticaria, severe patients will have exfoliative dermatitis, toxic epidermal necrolysis, acute generalized eruptive impetigo, etc.
; 2.
Liver damage: due to the excessive dosage of the drug, the patient shows symptoms such as general weakness, loss of appetite, anorexia and greasy, bloating, yellow staining of the mucous membrane and sclera; 3.
Granulocytopenia: the effect on the hematopoietic system is to cause granulocytopenia; 4.
Interstitial nephritis: long-term mass use will cause interstitial damage to the kidneys, causing interstitial nephritis, and severe patients will have abnormal
renal function.