Inventory: A selection of BMJ studies on August 22, 2020.

The increased risk of maternal mortality due to premature birth: https://doi.org/10.1136/bmj.m2533 Researchers recently examined the long-term risk of premature death associated with pregnant women in a population-based queue of women.
study, conducted in Sweden, involved 2189,477 women who gave birth between 1973 and 2015, and 76,535 (3.5%) of female participants died in 50.7 million follow-up years (the average age of death was 57.6 years).
In the 10 years following delivery, the adjusted risk ratio for all causes of premature birth (-lt;37 weeks) was 1.73, and when further strated, extremely premature (22-27 weeks) compared to full-term delivery (39-41 weeks) The adjusted risk ratio for all-cause mortality was 2.20, extreme predeteality (28-33 weeks) was 2.28, late preseedity (34-36 weeks) was 1.52, and early full-month delivery (37-38 weeks) was 1.19.
The above-mentioned risks continued to increase significantly during longer follow-up periods: for mothers who were premature and full-term, the adjusted risk ratio for all-cause death was 1.45 for 10-19 years after delivery and 1.37 for 20-44 years after delivery.
these findings do not appear to be attributable to common genetic or environmental factors within the family, including cardiovascular, respiratory diseases, diabetes and cancer.
. Air and family factors associated with childhood asthma research doi: https://doi.org/10.1136/bmj.m2791 Recently researchers examined air pollution and family-related risk factors associated with childhood asthma and persistent wheezing episodes.
study, a national case-control study, was conducted in Denmark and involved Danish children born between 1997 and 2014 with follow-up periods of 1-15 years of age or asthma and persistent wheezing episodes.
study found that children whose parents had asthma (with a corrected risk ratio of 2.29) and mothers who smoked during pregnancy (1.20) had a higher incidence of asthma, while those with higher levels of education (0.72) and higher incomes (0.85) had lower rates of asthma in their children.
exposure to particulate matter of 2.5 m (PM2.5), 10 m (PM10) and nitrate environments was associated with an increased risk of asthma and persistent wheezing, with a corresponding risk ratio of 1.05, 1.04 and 1.04 for each increase in concentrations of PM2.5, PM10, and nitrogen dioxide pollutants by 5 ?g/m3.
in different models and sensitivity analyses, only PM2.5 concentrations were positively associated with asthma and persistent wheezing risk.
: The impact of the self-management model on medical intervention and quality of life in asthma patients: https://doi.org/10.1136/bmj.m2521 Researchers conducted a systematic review and meta-analysis to examine the impact of the patient self-management model (multidisciplinary case management, self-management of regular medical support and minimal support) on the quality of life and medical intervention of asthma patients.
105 trials, including 27,767 participants.
in reducing health care, multidisciplinary case management (SMD-0.18) and regularly supported self-management (-0.30) were significantly better than conventional care.
in terms of quality of life, only regularly supported self-management (SMD 0.54) is statistically significant compared to routine care.
in studies of adolescents/children (5-18 years of age), only regularly supported self-management had significant benefits (health care use: SMD -0.21; quality of life: 0.23).
multidisciplinary case management (SMD -0.32) and regularly supported self-management (-0.32) are most effective in reducing the use of health care in patients with baseline severe asthma.
. ( 4) Radiotherapy in breast-preservation surgery to treat early breast cancer doi: https://doi.org/10.1136/bmj.m2836 Researchers recently examined the effectiveness and safety of single-dose radiotherapy in tumor excision in breast cancer patients.
the study was conducted at 32 centres in 10 countries, including the UK, Europe, Australia, the United States and Canada, involving 2,298 female breast cancer patients aged 45 and over who had leachate catheter cancer of less than 3.5 cm, CN0-N1, which met the conditions for breast-feeding treatment and was randomly divided into target intraoperative radiotherapy groups (TARGIT-IORT) or postoperative introphy radiotherapy groups (EBRT).
the EBRT group received 3-6 weeks of full mammary radiation therapy, the TARGIT-ORT group received radiotherapy immediately after the lump removal, and 80% of patients received only this radiotherapy.
study concluded that TARGIT-IORT was no less effective than EBRT: at 5 years of follow-up, the local recurrence rate of TARGIT-IORT group was 2.11%, while EBRT was 0.95% (difference was 1.16%).
, TARGIT-IORT reported 13 additional local relapses (24/1140 vs. 11/1158) compared to EBRT, but 14 fewer deaths (42/1140 vs. 56/1158).
follow-up (median 8.6 years, maximum 18.90 years) showed that the local recurrence rate between groups (risk ratio 1.13), the survival rate of breast-saving surgery (0.96), no far-end There was no significant difference between the transfer survival rate (0.88), the overall survival rate (0.82) and the breast cancer mortality rate (1.12), but the mortality rate for other causes in the TARGIT-IORT group decreased significantly (0.59).
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