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    Home > Biochemistry News > Biotechnology News > Is Alzheimer's linked to inflammation? Nature provides important evidence!

    Is Alzheimer's linked to inflammation? Nature provides important evidence!

    • Last Update: 2020-09-18
    • Source: Internet
    • Author: User
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    Alzheimer's disease (AD) is a neurodegenerative disease in which the brain has plaques of beta-amyloid protein.
    reveal the causes of these plaques and their role in disease progress is critical to developing strategies for the prevention and treatment of Alzheimer's disease.
    A growing body of research suggests that beta-amyloid proteins have antimicrobial and antiviral activity as part of the brain's innate immune response, suggesting a possible link between pathogen-inspired immune responses and the development of Alzheimer's disease.
    In a paper published September 2 in Nature, Professor Li Yuming of the Memorial Sloan Catherine Cancer Research Center found clear evidence of this link: interferon-induced transmembrane protein 3 (IFITM3) is involved in immune responses to pathogens that alter the activity of gamma-secretase, an enzyme that cut presuppressins into beta-amyloid fragments.
    and knocking out IFITM3 reduces the activity of gamma-secretion enzymes, thereby reducing the number of amyloid plaques in Alzheimer's mouse models.
    : Nature IFITM3 has a wide range of antiviral activity and is the first line of defense against infection.
    , IFITM3 is also part of the gamma-secretase complex.
    researchers found that IFITM3 expression levels were associated with gamma-secretion enzyme activity, and that knocking down or knocking out IFITM3 reduced the production of gamma-secretase activity and beta-amyloid protein.
    note that the excessive expression of IFT3 in the gene knock-out cell line restores the activity of the loss of gamma-secretase.
    effects of IFITM3 on gamma-secretase activity (Source: Nature) After analyzing a large number of mouse brain samples, the researchers found that aging was the number one risk factor for Alzheimer's disease, with levels of inflammatory markers and IFITM3 increasing with age The increase, and the observed increase in IFITM3 expression in some brain samples of patients with late-onset Alzheimer's disease (LOAD), means that IFITM3 may be a biomarker for identifying patients who may benefit from IFITM3 targeted therapy.
    the association of IFITM3 with gamma-secretion enzyme complexes in the human brain (Source: Nature) The mechanisms of inflammation and Alzheimer's disease revealed in this study.
    caused by viral infection or aging can lead to elevated IFITM3 levels, which increases gamma-secretion enzyme activity and leads to the production of human beta-amyloid proteins.
    The association between innate immunity and the production of beta-amyloid proteins and the risk of Alzheimer's disease (Source: Nature) Overall, this study identified IFITM3 as a new type of gamma-secretase-regulating protein and established a direct link between inflammation and the development of Alzheimer's plaques for the first time.
    researchers' next research project is to explore how IFAT3 interacts with gamma-secretase at the molecular and atomic levels and how IFAT3 is involved in neuroinstatic inflammation in animal models.
    , the researchers will also explore IFITM3 as a biomarker for Alzheimer's disease and a potential target for new drugs.
    : 1 s Hur, J. et al. The innate immunity protein IFITM3 modulates s-secretase in Alzheimer's disease. Nature (2020) 2 s Linksings to Alzheimer's disease development (Source: MedicalXpress)
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