Is amitriptyline effective for migraine?

Amitriptyline is a tricyclic drug used to treat migraine, depression and other emotional disorders Some doctors recommend amitriptyline to migraine patients to prevent these problems from causing headaches The drug is generally not used to treat headache symptoms, but it can be used as a preventive measure Like other tricyclic drugs, the drug affects neurotransmitter levels, and brain cells interact with the chemical Amitriptyline can effectively prevent the decomposition of chemicals such as norepinephrine and serotonin The reason this drug is effective against migraine is that when migraine attacks cause vasodilation, it constricts blood vessels by increasing serotonin levels Maintaining these vasoconstrictions will prevent further deterioration of the headache There are exact scientific results to support the use of amitriptyline to relieve migraine A study of 100 migraine patients in the United States found that 55% of them improved significantly four weeks after taking the drug, and that their migraines were reduced by at least half The antidepressant effect of amitriptyline is one of the reasons why it can treat some patients' headache In the studies mentioned above, patients with mild headache and those with severe headache who did not suffer from depression were significantly relieved by amitriptyline On the other hand, the frequency and severity of headache in depressive patients with severe headache almost relieved Potential side effects should be considered when giving patients a drug It should be known that amitriptyline can cause some side effects in the treatment of migraine, among which dry mouth, dizziness, nausea and nausea are the most common These adverse reactions do not need to see a doctor, and will disappear after a few days or weeks of treatment However, if there are serious side effects such as numbness of limbs, chest pain, confusion of thoughts or self thinking, you should see a doctor immediately Amitriptyline will interact with other drugs, which will limit its use and affect its efficacy Other tricyclic antidepressants, including monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs), can affect the therapeutic effect of amitriptyline on patients, even if used a few weeks ago Drinking can lead to emotional interaction and aggravate some side effects, especially when drinking a lot There are also potentially harmful interactions between rhythm drugs and other drugs used to treat mental illness.