Is curcucubin really so divine? Supporting liver health? Can improving cognitive levels and sperm quality lower cholesterol?

image Source:
Shutterstockin recent years, turmeric has caused a boom in the health community.the Global Dietary Trends Report released by Google in
2016, turmeric searches grew by
300%
in the past

5


;fact, turmeric (
Curcuma longa
) is a medicinal spice that India has eaten since ancient times, belonging to ginger plants and a natural vegetable dye. Curcubin is a natural active ingredient extracted from turmeric root stems and has a wide range of pharmacological effects. At present, curcubin has been found to have anti-inflammatory, antioxidant, anti-tumor, blood lipid regulation and other traditional health benefits. Michael
.
Grig also wrote in the Scientific Diet for Saving Life and Preventing Fatal Diseases:Curcubin may have an effect in preventing or treating lung disease, brain disease, and a variety of cancers, including multiple bone, colorectal, and pancreatic cancers
"
.and with the deepening of research, the potential health benefits of curcub are also being explored.supports liverSource:
iStockphoto one of the traditional uses of turmeric is to support liver health. A double-blind, placebo-controlled trial led by
Naveen Krishnareddy
of the Life Care Hospital in Bangalore, India, studied the effects of curcumin complex, a new curcumin complex with semi-milk saponin, that enhances the release of free curcumin and improves its bioavailableness.
[1]The double-blind, placebo-controlled study included
48,
people (
30
to
50
years old) who consumed
6,
or more of alcohol per week
(
in line with U.S. national alcohol abuse and Healthy male subjects of the Institute of Alcoholism
NIAAA
's Chronic Alcoholism Standard
)
were randomly divided into two groups for
8
weeks of
500 mg
curcumin complex or placebo. At the beginning of the trial, all subjects underwent a standard clinical evaluation and found elevated liver enzymes in all individuals, including serum transaminase and γ
-
glutamine transferase.
weeks, the placebo group's liver function markers increased by about
9.5%
, while the curcumin supplementation group improved significantly, including a
31% reduction in serum transaminase
, and a
γ-
glutamine transferase reduction of
29%
compared to the baseline. In addition, endoidant antioxidant activity increased in patients taking curcumin complex, while inflammatory response decreased significantly., curcubin can significantly improve liver health and function in patients with chronic alcoholism.improving the cognitive abilities of older adults Totograph:
iStockphoto 1 January


, 2018, researchers at the University of California, Los Angeles, published in The Age of America
The study, published in the Journal of Psychiatry,
analyzed the effects of curcutin on memory in people without dementia and the potential effects of curculin on tiny plaques and confusion in the brains of people with Alzheimer's disease.
[2]The double-blind, placebo-controlled study involved
40,
adults between the ages of
50 and 90
with mild memory impairment who were randomly divided into two groups, one taking curcubin twice a day at
90
mg) and the other taking a placebo for
18
months. At the beginning of the experiment, all participants underwent a standard cognitive assessment, which was then evaluated every
6
months, and the levels of curculin in their blood were monitored before and after
18
months. Of these,
30,
participants received additional
PET
imaging scans to detect amyloid and
tau
protein levels in their brains, which contain phosphate proteins associated with Alzheimer's disease.study found that curcub supplementation significantly improved participants' language and visual memory and attention compared to the placebo group. In the memory test, participants who took curcubin had a
28 percent
improvement in their memory levels, while their mood improved moderately. In addition,
PET
scan imaging data showed a significant decrease in the accumulation of amyloid and
tau
proteins in the amygdala of the curcubin group compared to placebo (the amygdala and the hemline are areas of the brain that control multiple memory and emotional functions).These findings suggest that curculin may reduce the accumulation of amyloid and
tau
proteins in the brain regions associated with mood and memory, while taking relatively safe curculin can provide meaningful cognitive benefits.Lowering Cholesterol and LipidsSource:
Adobe StockPlant Sterols
"
Cholesterol Natural Gram star
"
, which has good fat-lowering effects in patients with hypercholesterolemia, while curculin also has a fat-lowering and anti-inflammatory effect in preclinical studies. Therefore, both phytosterol and curcubin supplementation may perform better to optimize heart protection. So the
by researchers from the University of Newcastle, led by Jessica Ferguson
, is to assess the effects of curcutin supplementation in raising phytosterols to control cholesterol levels.
[3]The double-blind, randomized, placebo-controlled trial was conducted in
70,
individuals with hypercholesterolemia (average total cholesterol level of
6.57 mmol/L
) who were given a placebo
(PL
, without phytosterols or curculin
)
, and plant alcohols (
PS
,
2g/
days), curcubin (
CC
,
200mg/
days), or a mixture of phytosterols and curcubin
(PS-CC)
, lasts
4
weeks. The participants' total cholesterol on an empty stomach, LDL cholesterol, HDL cholesterol, triglycerides, total cholesterol and HDL cholesterol ratio (
TC
:
HDL-C
) were evaluated at the baseline and at the end of the study.the
PS
and
PS-CC
supplements, participants' total cholesterol, LDL cholesterol, and
TC
:
HDL-C
were significantly reduced. In
PS
group, total cholesterol was reduced by an average of
4.8%
, and low-density cholesterol was reduced by
8.1%
;
CC
intervention, total cholesterol and LDL cholesterol were reduced by
2.3%
and
2.6%
, respectively, while
PS-CC
intervention reduced total cholesterol by
11%
and LDL cholesterol by
14.4%
. In addition, plasma HDL cholesterol and triglyceride concentrations remained the same in all groups.results show that adding curculin to phytosterol therapy provides a greater cholesterol-lowering effect than phytosterol therapy alone.improving sperm qualityImage caption
Shutterstockinfertility is a common problem, with
25% of
couples seeking medical help for infertility in their relationships. Male infertility
the
in at least 50% of all cases. Sperm is also sensitive to the effects of reactive oxygen and free agents. Given curcubin's strong antioxidant and anti-inflammatory potential, researchers led by
Fatemeh Alizadeh
of the Medical University of Kazwen in Iran decided to study the effects of curcutin supplementation on male infertility.
[4]The randomized, double-blind, placebo-controlled trial, conducted in urology at infertility clinics, involved
60,
infertile men who were randomly divided into intervention groups and placebo groups
(n-30)
. Finally, 28

each group completed the study. Among them, the intervention group took
80
mg of curcugent daily, while the placebo group took a placebo for 10 weeks. Semen parameters, reproductive hormones, antioxidant function, and inflammatory factors were measured at the baseline and at the end of the study.at the end of the study, there were statistically significant differences in sperm count, concentration and vitality in both the intervention and control groups. Compared to placebos, curcumin supplementation can significantly improve sperm totals, sperm concentration, and sperm vitality. Curcubin is also statistically improved compared to placebo in terms of total antioxidant capacity and the reduction of propylene dues
(
antioxidant
)
and
c
reaction protein and tumor necrotic cause
(
inflammation measurement
)
. The results show that curcumin supplementation may be an effective treatment option to improve sperm quality in infertile men., turmeric is widely used for its unique bioactive function and health benefits. Tur
meric ranks first
traditional sales channels, according to the
HerbalGram
Market Report, released in
2018.

2017 sales exceeded $
5
0 million, making it the best-selling herbal supplement, and market research firm
Credence
reported that the global curcub market will continue to grow steadily during the forecast period
, with a global market capitalisation of $
84 million by
2
022
, it can be seen that curcutin is undoubtedly a hot spot in the market, both in terms of scientific research, bio-utilization improvement and the development of new products. : :
:
Krishnareddy N et al. “A novel curcumin-galactomannoside complex delivery system improves hepatic function markers in chronic alcoholics: a double-blinded, randomized, placebo-controlled study.” BioMed Research International. Published online September 23, 2018. [2]
：
Small GW et al. “Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-control