Is finding a simple chemical reaction for a new drug equally effective?

In an analysis by AstraZenecom scientists (doi.org/10.1016/j.drudis.2020.09.027), the authors want to see if new biological functions necessarily require new chemical reactions.
the authors looked for two groups of compounds, each with 10,000 compounds, that had been screened by at least two projects.
one group was synthesized by a simple alamide bond reaction and the other group did not contain aamide bond, resulting in a large difference between the two groups of compounds evaluated by calculating chemical common measures of complexity, diversity and novelty.
proportion of active compounds is also basically the same, other chemical and chemical properties such as hydrophobic, molecular weight is also close.
the authors conclude that chemists love simple reactions that are not lazy, but that simple reactions can also find good medicine.
the large-scale commercialization of synthetic acetates and organic amines is one of the main drivers.
of the main functional molecules of the drug source analysis organism is protein, which is formed by 20 amino acids in different sequences by the amamine bond.
amide bonds are also the most reliable chemical reactions in organic chemistry, perhaps because of the structural similarity with proteins many synthetic peptide biological activity is very good, which also drives chemists to the synthesis of acetamide bonds, there are now many kinds of even reagents used in the production of various alamide bonds.
the authors, 1/3 of Aslecon's new compounds contain alamide bonds, which shows the prevalence of this reaction.
but some say the compound is so common because chemists are too lazy, as farmers love to grow corn, not because everyone loves corn, but because corn yields are highest.
this analysis refutes this view to some extent, but it does not completely deny that alamide compounds have been infested.
compounds are synthesized in search of new drugs, and the dosing is highly specific and intense with the highly strict binding chamber of the protein, while maintaining a certain pharmacogenetic properties to become a drug.
the binding chamber of each protein is different, just as each consumer has a different taste.
some people love corn, but if you only grow all kinds of corn love sweet potato consumers set up an isolated group.
many proteins have very strict requirements for the molecular skeleton of the mating body, and not every protein compound can be replaced with an alamide compound.
In fact, some targets are very strict, not to mention the use of alamide bonds, any changes are not allowed, such as several successfully listed proton pump inhibitors, yew alcohol family drugs as if designed by a person, rather than from different companies.
proteins are not only unable to bind effectively, but now no known family of compounds can bind effectively.
is what is often called a non-drug target, which is estimated to account for the vast majority of in-cell targets.
the authors' evaluation of compound quality also need to be examined in a larger context.
does not say whether the computational chemical indicators that measure diversity, complexity, and novelty are reasonable, even if they are reasonable, do not necessarily accurately reflect the value of the compound.
possible chemical space is almost infinite, and it is estimated that the total amount of material that can be synthesized into 1 milligram of each possible compound throughout the solar system is not enough, but the vast majority are of no drug value.
so you can have a very diverse, very complex library of very complex compounds, but it may not be worth a dime.
Just as a bike requires that the front and rear wheels must be between the three key components, one pedal and one chain link, and you link the two wheels with any other nature components are not a bicycle, so it's no use how many different types of complex accessories you have.
may not be worse than other official groups, but it is not an easy substitute for other official groups.
not discriminate against alamide, its simple and efficient nature is indeed an abuse risk.
overuse of this reaction not only wastes opportunity costs, but also makes local chemical space more crowded and creates patent risks.
new drug design protein structure is God, protein requirements for the mating body do not consider whether your chemical tools are good use.
if your target requires that the dragonfly be original, divorce is not possible.
Of course, the requirements of new targets for liants drive the invention of new chemical reactions, many of which are now invented in the process of full synthesis of natural products, and one of the main drivers of natural product synthesis is the search for new drugs.
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