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    Home > Biochemistry News > Biotechnology News > Is it effective in treating neuropathical eye pain caused by dry eye disease?

    Is it effective in treating neuropathical eye pain caused by dry eye disease?

    • Last Update: 2020-07-29
    • Source: Internet
    • Author: User
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    Dry eye disease is a common cause of chronic eye pain, which is associated with eye discomfort, pain and visual impairment caused by tear fluid dysfunction and eye surface damageDue to the high density of corneal injury receptors, the position of the shallow, corneal sensory neural pathway damage or dysfunction is considered to be part of dry eye disease in some patientsPersistent damage or inflammation on the surface of the eye may lead to abnormal activation of sensory fibers in the eye, leading to chronic neuropathic eye painNeuropathic eye pain is characterized by sensory disorders (unpleasant abnormal sensations), spontaneous pain, abnormal pain triggers (pain responses to harmless stimuli including light and wind) and pain allergies (excessive pain for harmful stimuli)Neuropathic mechanisms need to be considered when the response to the treatment of tear fluid dysfunction is inadequateCentral sensitization is the result of continuous activation and peripheral sensitization of the injury receptorThe continuous activity of the corneal injury receptor promotes the release of glutamate, an inlysate neuron, before synapses, leading to the activation of the N-methyl-d-tatininine (NMDA) receptorBecause of the effect of gabapentin on the central pain pathway, it is often used to treat chronic neuropathic painGabapentin is a class I, A-level molecule in neuropathical pain therapy, which reduces the release of a variety of excitatory neurotransmitters and increases the concentration of gamma-aminobutyric acid (GABA) by binding to the pre-synaptic N-type voltage-gated calcium channel alpha2 sub-subtypeIn 2011, a study reported that Gabapentin significantly reduced postoperative eye pain after refractive cornea cuttingRecent studies have also compared the effects of garbardin use in dry eye patientsThe researchers studied 72 patients at the Neurology and Ophthalmology Clinic at Berdur State HospitalNeurogenic pain screening was performed on neurologic outpatients using the Pain Detection Questionnaire (PD-Q)PD-Q is designed to screen for symptoms and signs of neuropathy without a physical examination, and is a reliable and effective measure of neuropathic components that determine chronic pain in patientsPatients with a PD-Q score of 18 were considered positive for neuropathyAll selected patients are evaluated based on dry eye performance after routine eye clinic examinationsPatients were divided into two groups: the first group (n:36), the artificial tear and cyclosporine eye drops treatment group and the second group (n:36), the artificial tear, cyclosporine ophthalmic and gabadin treatment groupsPatients with severe DED were considered to have severe DED( according to the OSDI questionnaire (score 0-100, with a higher score representing greater disability) and treated with artificial tear and cyclosporine dropsGabapentin therapy starts on day 1 with 600 mg/day (300 mg, twice a day), 900 mg/day (300 mg, three times a day) on day 2, and dispenses to 1800-2400 mg/day according to pain relief needsIt was found that gabapentin therapy significantly improved dry eye evaluation test scores and eye pain compared to surface therapyThe implication of this study is that the treatment of severe dry eye patients should be supplemented by central drugs such as gabartineDry eye disease should not only be considered limited to the eyes, but should also be considered for systemic treatmentIf patients with dry eye do not respond adequately to local surface therapy, neurological factors should be consideredThe assessment of non-eye neuropathy symptoms may indicate the presence of systemic neuropathy, as well as central sensitization, which is the cause of eye painThis provides a new way of thinking for the drug treatment strategy of dry eye diseaseReferences: Ongun N, Ongun GTIs gabapentin effective in dry eye disease and neuropathic ocular pain? (published ahead online of print, 2019 May 27Acta Neurol Belg2019; 10.1007.
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