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▎The content team editor of WuXi AppTec today, an important study published in the New England Journal of Medicine showed that pregnant women who received the mRNA COVID-19 vaccine showed no obvious risk.
Screenshot source: The New England Journal of Medicine In the United States, many pregnant women are vaccinating the mRNA new crown vaccine, but the safety information related to the vaccination of pregnant women is limited.
Researchers from the US Centers for Disease Control and Prevention used the v-safe after vaccination health checker system (v-safe after vaccination health checker), v-safe pregnancy registry (v-safe pregnancy registry), and v-safe vaccine adverse event reporting system (VAERS) data analyzes the preliminary safety of pregnant women vaccinated with the mRNA new crown vaccine during the period from December 14, 2020 to February 28, 2021.
During the study period, a total of 35,691 women aged 16-52 in the v-safe system were confirmed to be pregnant.
Compared with non-pregnant women, pregnant women have more pain at the injection site and less headaches, muscle pains, chills and fever.
Among the 3958 subjects registered in v-safe pregnancy, 827 completed pregnancy, 115 (13.
9%) had miscarriage and 712 (86.
1%) had live births (mainly in the third trimester of vaccination) Of subjects).
Adverse neonatal outcomes included premature delivery (9.
4%) and small-for-gestational-age infants (3.
2%) (intrauterine growth retardation or small-like infants); no neonatal deaths were reported.
Although it is difficult to directly compare, the proportion of women who have completed pregnancy after receiving the new coronavirus vaccine has a rate similar to the incidence before the new coronavirus pandemic.
Among the 221 pregnancy-related adverse events reported by VAERS, spontaneous abortion (46 cases) occurred most frequently.
Image source: 123RF research shows that among pregnant women receiving the mRNA new crown vaccine, preliminary research results did not show significant safety issues.
In the future, a large number of women who were vaccinated in the first trimester will need to be followed up.
In addition, there is also new evidence that after maternal immunization with the new crown vaccine in the third trimester of pregnancy, the new crown virus antibodies are transferred through the placenta, indicating that maternal vaccination may provide a certain level of protection for the newborn.
However, there is currently a lack of specific data on the impact of vaccination time on antibody transfer and degree of protection.
The research team pointed out that v-safe participation is voluntary, and registration information is not uniformly available at all vaccination sites.
Therefore, the surveyed population may have potential biases in terms of age, race, sociodemographics, and clinical characteristics, which limits the comparability of the outcome with previous data.
The US Centers for Disease Control and Prevention and the US FDA are continuing to monitor and report information on the safety of mRNA and other types of new coronavirus vaccines in pregnant people.
New crown research related readings.
What are the effects of the new crown vaccine during breastfeeding? JAMA reports that the protection of breast milk antibodies and maternal and child safety data is 67% effective, and the 10 million people of Kexing's new crown vaccine released by real-world research and release of the new crown vaccine have been infected and died? The real data of 75 million vaccinators in the United States is released.
A number of scientific studies emphasized that a "little matter" is very important.
Source: 123RF Reference: [1] Tom T.
Shimabukuro, MD et al.
(April 21, 2021,).
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons.
DOI: 10.
1056/NEJMoa2104983 Note: This article aims to introduce the progress of medical and health research, not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
Screenshot source: The New England Journal of Medicine In the United States, many pregnant women are vaccinating the mRNA new crown vaccine, but the safety information related to the vaccination of pregnant women is limited.
Researchers from the US Centers for Disease Control and Prevention used the v-safe after vaccination health checker system (v-safe after vaccination health checker), v-safe pregnancy registry (v-safe pregnancy registry), and v-safe vaccine adverse event reporting system (VAERS) data analyzes the preliminary safety of pregnant women vaccinated with the mRNA new crown vaccine during the period from December 14, 2020 to February 28, 2021.
During the study period, a total of 35,691 women aged 16-52 in the v-safe system were confirmed to be pregnant.
Compared with non-pregnant women, pregnant women have more pain at the injection site and less headaches, muscle pains, chills and fever.
Among the 3958 subjects registered in v-safe pregnancy, 827 completed pregnancy, 115 (13.
9%) had miscarriage and 712 (86.
1%) had live births (mainly in the third trimester of vaccination) Of subjects).
Adverse neonatal outcomes included premature delivery (9.
4%) and small-for-gestational-age infants (3.
2%) (intrauterine growth retardation or small-like infants); no neonatal deaths were reported.
Although it is difficult to directly compare, the proportion of women who have completed pregnancy after receiving the new coronavirus vaccine has a rate similar to the incidence before the new coronavirus pandemic.
Among the 221 pregnancy-related adverse events reported by VAERS, spontaneous abortion (46 cases) occurred most frequently.
Image source: 123RF research shows that among pregnant women receiving the mRNA new crown vaccine, preliminary research results did not show significant safety issues.
In the future, a large number of women who were vaccinated in the first trimester will need to be followed up.
In addition, there is also new evidence that after maternal immunization with the new crown vaccine in the third trimester of pregnancy, the new crown virus antibodies are transferred through the placenta, indicating that maternal vaccination may provide a certain level of protection for the newborn.
However, there is currently a lack of specific data on the impact of vaccination time on antibody transfer and degree of protection.
The research team pointed out that v-safe participation is voluntary, and registration information is not uniformly available at all vaccination sites.
Therefore, the surveyed population may have potential biases in terms of age, race, sociodemographics, and clinical characteristics, which limits the comparability of the outcome with previous data.
The US Centers for Disease Control and Prevention and the US FDA are continuing to monitor and report information on the safety of mRNA and other types of new coronavirus vaccines in pregnant people.
New crown research related readings.
What are the effects of the new crown vaccine during breastfeeding? JAMA reports that the protection of breast milk antibodies and maternal and child safety data is 67% effective, and the 10 million people of Kexing's new crown vaccine released by real-world research and release of the new crown vaccine have been infected and died? The real data of 75 million vaccinators in the United States is released.
A number of scientific studies emphasized that a "little matter" is very important.
Source: 123RF Reference: [1] Tom T.
Shimabukuro, MD et al.
(April 21, 2021,).
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons.
DOI: 10.
1056/NEJMoa2104983 Note: This article aims to introduce the progress of medical and health research, not a treatment plan recommendation.
If you need guidance on treatment plans, please go to a regular hospital for treatment.
