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    Home > Food News > Food Articles > Is there any basis for "motherhood"? Scientists have discovered this

    Is there any basis for "motherhood"? Scientists have discovered this

    • Last Update: 2021-03-03
    • Source: Internet
    • Author: User
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    a widely circulated phrase, "Mother is just" is no longer just an idiom, but has a scientific basis. Reporters learned from Tsinghua University, the institute of immunology Bohai research group of the latest research shows that the human body in the pathogen attack, women than male individuals will produce a stronger body fluid immune response, in particular, can produce more antibodies to achieve self-protection, such as we are familiar with hepatitis B, hepatitis C virus; In addition, vaccination to produce protective antibodies to prevent infectious diseases is often better in women than in men, such as the hepatitis B triple vaccine, which is commonly given.
    reporter learned that the latest work of the Bohai task force revealed the specific biological mechanisms that lead to the gender differences in the immune response of this antibody, thus providing new ideas and potential targets for enhancing the effectiveness of vaccination and the treatment of antibody-mediated autoimmune diseases. The study, entitled "Gender-secondaryity of body fluid immune response caused by GPR174-CCL21 distribution modules," was published online today in the journal Nature.
    for all mammals, the mother directly assumes the responsibility of conceived the fetus and feeding future generations. The fetus and newborn's own immune system is not yet sound and mothers are needed to help prevent the infection of pathogens in a variety of ways. One of the most important ways is for a mother to transfer antibodies that have been produced in her body to her child during pregnancy through the placenta and breast milk during lactation. The stronger a mother's ability to produce antibodies, the more likely she is to pass on enough antibodies to her child to prevent disease. "From a biological evolutionary perspective, Bohai explains why mothers need a strong antibody immune response.
    the task force, is to find out exactly what specific biological mechanisms in the male and female individuals caused the antibody immune response of the strength of the difference. "Studying this problem makes it possible to find new ways to improve the effectiveness of vaccination in men and to combat antibody autoimmune diseases, which affect women in particular." Mr Bohai said.
    , antibodies are produced when B lymphocytes receive antigen stimulation and differentiate into plasma cells. In order to differentiate more effectively into plasma cells and produce more kinds and quantities of antibodies, B lymphocytes need to be transferred from the vesicle region to the hair center and undergo a process called affinity maturation. The study found that a group of mediated receptors were involved in the above process in the hair center, and the G protein conjunctivity GPR174 on the X chromosome could feel the coercion factor CCL21. In male mice, the coercion factor CCL21 promoted the combination of GPR174 and G protein G alphai, inhibited the migration of B cells to the center of development, and the level of body fluid immune response decreased, while GPR174 in female mice did not.
    "Although GPR174 controls the positioning of B-cell birth centers should not be the only mechanism that causes female-male differences, male individuals are able to rely on hormones at specific stages of the immune response, regulate the coupling efficiency of specific GCR and G-alpha proteins on specific cells, so as to fine-tune the antibody immune response to achieve a different balance from females, which has to be lamented by nature's ingeniousness. Bohai introduced that their next step will be to explore in depth how hormones regulate GPCR-G alpha protein coupling, GPR174 and CCR7 in CCL21 ligation stimulation how synergy or antagonistic, how these processes affect the function of B cells and autoimmune diseases in the human body, hoping to develop drugs for GPR174 and its associated process mechanisms, with a view to enhancing the effectiveness of vaccination.
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