Is there no cure for advanced cancer?

Ovarian cancer stage IV, metastases in more than 20 parts of the body, severe ascites, tumor markers exceeding the standard by nearly 200 times, intestinal tumor compression and obstruction, unable to eat, even drinking water, predicting that there are only three months left in life.

The test results surprised Ms.

Similar to Ms.

The treatment of malignant tumors has always been a difficult problem in the medical field.

Cheng Zhongping, director of the Obstetrics and Gynecology Department of Shanghai Tenth Hospital, said that lymphocytes, namely TILs (tumor infiltrating lymphocytes), are important immune cells, especially lymphocytes that successfully enter the tumor tissue and survive, and can specifically recognize and kill tumor cells.

As a result, some medical scientists who dare to explore put forward the idea: to extract the lymphocytes that have infiltrated into the tumor, purify, activate, expand, and further develop and grow, in order to kill tumor cells and achieve effective treatment

Through hospital-enterprise cooperation in the early stage, clinicians from the Obstetrics and Gynecology Department of the Tenth Hospital participated in the cell model and animal model trials of TIL therapy throughout the process

It was at this time that Ms.

The first step of TIL therapy is to surgically remove some tumor lesions and then extract the lymphocytes.

Just as lucky as Ms.

At present, the clinical research of Shanghai No.

Cheng Zhongping introduced that TIL is an attempt after the existing conventional therapies for advanced tumors have failed.

It is reported that the new generation of TIL therapy enhances the expression of a target gene of interest through electrotransfection technology, or knocks out (KO) a specific gene through technologies such as CRISPR or TALEN.

Author: Li Chenyan Shengxing

Editor: Li Chenyan

Responsible editor: Tang Wenjia

*Wenhui's exclusive manuscript, please indicate the source for reprinting