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verywellhealth
verywellhealthThe understanding of the three-dimensional (3D) morphology of the human endometrium can promote our understanding of the mechanism of endometrial regeneration and implantation of fertilized eggs, as well as clarify menstrual disorders, infertility and endometrial-related diseases (such as intrauterine The pathogenesis of endometriosis) adenomyosis, endometriosis, endometrial hyperplasia and endometrial cancer.
Endometrial glands are composed of complex winding and branch structures, and traditional 2D imaging techniques cannot fully evaluate their shape.
The 3D structure of human endometrial and adenomyosis is constructed through the latest 3D tissue removal imaging technology, which provides new insights for the study of endometrial in the past century.
The research team led by Prof.
It was found that the human endometrial glands formed a complex plexiform network in the basal layer, called a "rhizome" structure.
3D image of normal human endometrial tissue.
Blood vessel
The human endometrium is a dynamic tissue that changes its shape and function every month in response to ovarian hormones.
prevention
In their previous genomic study in 2018, the researchers tried to provide an understanding of the origin of endometriosis and clarify the relevant molecular features.
Ovarian cancer
As the lead researcher Professor Enomoto pointed out: "Our 3D imaging technology establishes a baseline for the 3D structure of human endometrial glands and adenomyosis.
Although extensive research is needed in the field of obstetrics and gynecology to determine the mechanisms of normal endometrial function and related diseases, this research can provide the first novel insights into the 2D shape of human endometrial tissue in nearly a century.
But this research can provide the first novel insights into the 2D shape of the human endometrium in nearly a century, a contemporary 3D model of tissue.
Three-dimensional understanding of the morphological complexity of the human uterine endometrium.
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