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Original author: Max Kozlov's study found that the risk of severe illness among people over 60 has been reduced by nearly 20 times, but some people question the role of the third injection
.
A high-profile study published on September 15 [1] showed that elderly Israelis who received the third shot of the new crown vaccine tested positive for the new crown virus (SARS-CoV-2) or had severe COVID-19 The probability is much lower than that of the elderly who only received two injections
.
The standard vaccination procedure for the new crown mRNA vaccine is two shots, but some governments (including the Israeli government) have already started the third "boost shot"
.
This latest study counts 1.
1 million elderly people over 60 years old in Israel
.
At least 5 months have passed since the first two injections were given to these elderly people .
Twelve days or more after they finished the third injection, in a similar period of time, people who received three injections were about 19.
5 times less likely to develop severe COVID-19 disease than their peers who received only two injections.
.
Residents in a nursing facility in Israel are receiving a third dose of the new crown vaccine
.
Source: Nir Alon/Zuma Press "The results are very convincing," said Susan Ellenberg, a biostatistician at the University of Pennsylvania.
These data may be the strongest evidence she has seen to support the strengthening needle
.
However, potential deviations in the data make it impossible for some scientists to be sure that all populations must be given booster shots, and these data cannot eliminate concerns about vaccine fairness—after all, billions of people have not even received a shot
.
Israel has implemented a universal vaccination program very early, and in July this year began to provide the third dose of Pfizer-BioNTech vaccine to people aged 60 and above
.
This latest analysis found that the third shot is not only related to the significant decrease in the severe COVID-19 rate, but also to the 11.
3 times drop in the new coronavirus infection rate
.
But Boston University epidemiologist Ellie Murray reminded that observational studies represented by this kind of analysis have some difficult to detect and statistical deviations
.
For example, people who sign up for booster shots may have different COVID-19 risks or have different performances than people who have not received booster shots
.
Ellenberg said that the research team tried to reduce some of these potential deviations, even if they could not remove all the deviations, but from the extent of the effect, it can be known that the enhanced needle can indeed provide some protection, at least in the short term
.
As of the time of posting, the reporter could not contact the author of the study
.
Global impact Just as the results of this study were published, a large number of wealthy countries were considering promoting and strengthening the needle
.
An advisory committee of the U.
S.
Food and Drug Administration (FDA) discussed Pfizer's application for an enhanced injection to the United States on September 17
.
One of the authors of the Israeli study also plans to report data to the committee
.
Murray believes that considering the potential bias in the data and insufficient evidence that immunity will weaken after vaccination, the latest results cannot indicate that there is an "urgent need" for booster injections
.
She said: "From the perspective of public health, the influence of the former is much greater than that of the latter
.
"Murray is not the only scientist who believes that the Israeli research results are not sufficient to prove that the booster needle is reasonable
.
In a review article published on September 13 [2], a team including two senior FDA scientists cited a A preprint paper [3], and pointed out that the short-term protection effectiveness seen in Israel “does not necessarily mean the existence of long-term benefits
.
”
Dvir Aran is a biomedical data scientist at the Technion Institute of Technology in Israel .
It is to stop the spread of the virus among young people and prevent severe illness and death among the elderly
.
"Is this the best way? Will the lockdown for two weeks have a similar effect? "I can't answer this question," he said, "but this method is very interesting.
It is to rely on vaccines to stop an epidemic of this scale
.
"References: 1.
Bar-On, YM et al.
N.
Engl.
J.
Med.
https://doi.
org/10.
1056/NEJMoa2114255 (2021).
2.
Krause, PR et al.
Lancet https:// doi.
org/10.
1016/S0140-6736(21)02046-8 (2021).
3.
Bar-On, YM et al.
Preprint at medRxiv https://doi.
org/10.
1101/2021.
08.
27.
21262679 (2021).
Published in the news section of Nature on September 16, 2021 with the title COVID-vaccine booster shot shows promise in Israeli study © naturedoi: 10.
1038/d41586-021-02516-4 Read the related article Five Questions and Five Answers for the New Coronary Vaccine Booster Injection | "Nature" Long Article Will India Launch the World's First New Coronary DNA Vaccine Will Children and Adolescents Need New Coronary Vaccine? Copyright Statement: This article is in charge of Springer Nature Shanghai Office Translation
.
The
content in Chinese is for reference only, and the original English version shall prevail for all content
.
.
A high-profile study published on September 15 [1] showed that elderly Israelis who received the third shot of the new crown vaccine tested positive for the new crown virus (SARS-CoV-2) or had severe COVID-19 The probability is much lower than that of the elderly who only received two injections
.
The standard vaccination procedure for the new crown mRNA vaccine is two shots, but some governments (including the Israeli government) have already started the third "boost shot"
.
This latest study counts 1.
1 million elderly people over 60 years old in Israel
.
At least 5 months have passed since the first two injections were given to these elderly people .
Twelve days or more after they finished the third injection, in a similar period of time, people who received three injections were about 19.
5 times less likely to develop severe COVID-19 disease than their peers who received only two injections.
.
Residents in a nursing facility in Israel are receiving a third dose of the new crown vaccine
.
Source: Nir Alon/Zuma Press "The results are very convincing," said Susan Ellenberg, a biostatistician at the University of Pennsylvania.
These data may be the strongest evidence she has seen to support the strengthening needle
.
However, potential deviations in the data make it impossible for some scientists to be sure that all populations must be given booster shots, and these data cannot eliminate concerns about vaccine fairness—after all, billions of people have not even received a shot
.
Israel has implemented a universal vaccination program very early, and in July this year began to provide the third dose of Pfizer-BioNTech vaccine to people aged 60 and above
.
This latest analysis found that the third shot is not only related to the significant decrease in the severe COVID-19 rate, but also to the 11.
3 times drop in the new coronavirus infection rate
.
But Boston University epidemiologist Ellie Murray reminded that observational studies represented by this kind of analysis have some difficult to detect and statistical deviations
.
For example, people who sign up for booster shots may have different COVID-19 risks or have different performances than people who have not received booster shots
.
Ellenberg said that the research team tried to reduce some of these potential deviations, even if they could not remove all the deviations, but from the extent of the effect, it can be known that the enhanced needle can indeed provide some protection, at least in the short term
.
As of the time of posting, the reporter could not contact the author of the study
.
Global impact Just as the results of this study were published, a large number of wealthy countries were considering promoting and strengthening the needle
.
An advisory committee of the U.
S.
Food and Drug Administration (FDA) discussed Pfizer's application for an enhanced injection to the United States on September 17
.
One of the authors of the Israeli study also plans to report data to the committee
.
Murray believes that considering the potential bias in the data and insufficient evidence that immunity will weaken after vaccination, the latest results cannot indicate that there is an "urgent need" for booster injections
.
She said: "From the perspective of public health, the influence of the former is much greater than that of the latter
.
"Murray is not the only scientist who believes that the Israeli research results are not sufficient to prove that the booster needle is reasonable
.
In a review article published on September 13 [2], a team including two senior FDA scientists cited a A preprint paper [3], and pointed out that the short-term protection effectiveness seen in Israel “does not necessarily mean the existence of long-term benefits
.
”
Dvir Aran is a biomedical data scientist at the Technion Institute of Technology in Israel .
It is to stop the spread of the virus among young people and prevent severe illness and death among the elderly
.
"Is this the best way? Will the lockdown for two weeks have a similar effect? "I can't answer this question," he said, "but this method is very interesting.
It is to rely on vaccines to stop an epidemic of this scale
.
"References: 1.
Bar-On, YM et al.
N.
Engl.
J.
Med.
https://doi.
org/10.
1056/NEJMoa2114255 (2021).
2.
Krause, PR et al.
Lancet https:// doi.
org/10.
1016/S0140-6736(21)02046-8 (2021).
3.
Bar-On, YM et al.
Preprint at medRxiv https://doi.
org/10.
1101/2021.
08.
27.
21262679 (2021).
Published in the news section of Nature on September 16, 2021 with the title COVID-vaccine booster shot shows promise in Israeli study © naturedoi: 10.
1038/d41586-021-02516-4 Read the related article Five Questions and Five Answers for the New Coronary Vaccine Booster Injection | "Nature" Long Article Will India Launch the World's First New Coronary DNA Vaccine Will Children and Adolescents Need New Coronary Vaccine? Copyright Statement: This article is in charge of Springer Nature Shanghai Office Translation
.
The
content in Chinese is for reference only, and the original English version shall prevail for all content
.
