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Issue 21/2021 - L-Homoserine achieves 50% efficient conversion

 Last Update: 2022-11-14
 Source: Internet
 Author: User

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pure amino acids

acid design

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Recently, the research team of the Institute of Microbiology of the Chinese Academy of Sciences has made the fermentation level of L-homoserine exceed 84 g/L through systematic metabolic engineering transformation and fermentation process improvement, and the conversion rate has reached 50%, which has good economy
.

Through the pathway coupling design, the research team established a fermentation path with an overall balance of reducing power, and reused the carbon dioxide released in the reducing force supply pathway, and the designed pathway realized the fermentation of glucose to L-homoserine without loss of carbon element
.
This study lays a foundation for the industrial production of L-homoserine, and provides a new idea
for improving the yield of other aspartic acid amino acids.

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