It is found that a class of experimental drugs can be used to treat skin allergy and hair loss

Recently, researchers from Johns Hopkins University have successfully used a group of experimental drugs (http:// to cure skin allergies and alopecia caused by high-fat diet The researchers said the compound inhibited the production of sphingolipids, which are components of the skin and cell membranes At present, the research shows that mice are more likely to have symptoms such as hair whitening, hair loss and dermatitis after receiving a high-fat diet, and the above symptoms can be alleviated by feeding drugs For this result, the researchers said that this does not mean that it is also applicable to humans, and there is no evidence that the compound is safe at the human level But this discovery can provide new ideas for the treatment of alopecia and dermatitis In order to study how to affect the skin color and state through the destruction of sphingomyelin, and whether D-PDMP can inhibit the production of GSL, the author first fed different types of feed to mice for 8 weeks The results showed that: compared with the normal diet, the hair loss of mice receiving high-fat diet increased This effect became more significant with the increase of mice diet The researchers also observed the skin state of mice by microscopy, and found that mice receiving high-fat diet had neutrophil infiltration, while the effect of D-PDMP treatment, in which the number of neutrophils decreased significantly, indicating that skin inflammation was alleviating The researchers compared levels of sphingolipids and ceramide by mass spectrometry Compared with the normal diet mice, the proportion of glycosphingolipid and ceramide in the high-fat diet mice decreased significantly, but the ceramide level increased significantly after the drug treatment