It is found that long-term intake of edible oil can promote the development of breast cancer

Recently, published in cancer prevention research, a study led by scientists from the University of Illinois at Urbana Champaign (UIUC) found that after long-term intake of repeatedly used cooking oil, the gene expression in mice will change, promoting the development of breast cancer In the study, the scientists divided the mice into two groups: one group ate fresh and unheated soybean oil, the other group ate soybean oil which had been repeatedly treated with high temperature, and the intake was adjusted according to the weight of the mice After 16 weeks, the researchers injected mice with advanced breast cancer cells to see how the aggressive cells reacted in different mice Twenty days after the injection, the researchers began to observe the distribution of tumor cells They found that the primary tumors at the injection site were 4 times as large as those in the control group! What's worse, in these mice, tumors are also more likely to metastasize Although the injection site of these cells is the tibia of mice, just 20 days later, a lot of tumor metastasized to the lungs of mice The researchers tried to answer the reasons behind the phenomenon In the experimental group of mice, the researchers found that they had a significant increase in the level of a protein called Ki-67, which is related to cell proliferation, in lung metastases However, gene expression analysis (http:// found that compared with the control group, 455 genes in the experimental group had more than two times changes in expression level, many of which were related to oxidative stress According to this, the researchers put forward their hypothesis: if the oil is used repeatedly at high temperature, the triglycerides will break and the free fatty acids will be oxidized, which will increase the acrolein level in the oil This substance is known to have carcinogenic properties Under a series of factors, the gene expression level of mice changed, which "promoted the metastasis of breast cancer to a certain extent at least" In addition, they point out that many biologists are studying the mechanism behind tumor metastasis, and their results are expected to include dietary factors in the discussion For example, many cancer survivors have not really recovered They still have dormant cancer cells in their bodies If the repeated use of oil can promote the metastasis of cancer, it may be a wise choice to keep more heart in the diet Of course, the current research results are simple Whether this approach is useful or not requires more human research results.