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    Home > Active Ingredient News > Drugs Articles > It is found that microtubules play a key role in the development of diabetes

    It is found that microtubules play a key role in the development of diabetes

    • Last Update: 2019-08-12
    • Source: Internet
    • Author: User
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    Recently, scientists from Vanderbilt University have elucidated the key role of microtubules in the development of diabetes Relevant research items are published in the international journal Current Biology In the past 10 years, researchers have found that microtubules, as the skeleton of cells, play a key role in regulating the transport of insulin particles to the cell membrane for secretion In this study, the researchers found that microtubules are essential for the biosynthesis of insulin granules (http:// The results show that glucose can regulate the function of microtubules through the ubiquitous information molecule cyclic AMP and its effector protein Epac2 Glucose signal can promote the decomposition and reassembly of microtubules in the Golgi matrix, where insulin particles will form Inhibition of Epac2 can block the formation of new Golgi derived microtubules and eventually lead to the elimination of insulin particles in β cells The results of this study suggest that the dynamic changes of regulatory microtubules may help to develop new potential therapies for diabetes.
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